Medrol 4 mg (Tablet)
Unit Price: ৳ 7.52 (10 x 10: ৳ 752.00)
Strip Price: ৳ 75.20
Medicine Details
| Category | Details |
|---|---|
| Generic | Methylprednisolone |
| Company | Pfizer |
| Also available as |
Indications
- Endocrine Disorders
- Rheumatic Disorders
- Collagen Diseases
- Dermatologic Diseases
- Allergy
- Ophthalmic Diseases
- Respiratory Diseases
- Hematological Disorders
- Neoplastic Diseases
- Edematous States
- Gastrointestinal Disease
- CNS Disease
Description
- Potent anti-inflammatory steroid
- Greater anti-inflammatory potency than Prednisolone
- Low tendency to induce sodium and water retention
- Relative potency to Hydrocortisone is at least four to one
Pharmacology
- Potent anti-inflammatory agent
- Profoundly inhibits the immune system
- Binds to and activates intracellular glucocorticoid receptors
- Affects kidney, fluid & electrolyte balance, lipid, protein, carbohydrate metabolism
- Influences skeletal muscle, cardiovascular system, immune system, nervous system, endocrine system
Dosage & Administration
- Usual range is 2-48 mg daily in divided doses
- Initial dosage may vary from 4-48 mg per day depending on the disease entity
- Maintenance dosage determined by decreasing initial dose gradually
- Specific dosing guideline for severe allergy and dermatitis
- Alternate-day therapy recommended for long-term pharmacologic dose treatment
Interaction
- Inhibition of metabolism by Erythromycin, Clarithromycin, Phenobarbital, Phenytoin, Rifampin, Ketoconazole
- Estrogens can increase corticosteroid effect by 50%
- Interaction with Cyclosporin and blood thinners like Warfarin
Contraindications
- Systemic fungal infections
- Known hypersensitivity to components
Side Effects
- Short courses usually well-tolerated with few mild side effects
- Long term, high doses may produce serious side effects
- Range of side effects from mild annoyances to serious damage
- Potential side effects include fluid retention, weight gain, high blood pressure, potassium loss, headache, muscle weakness
Pregnancy & Lactation
- Pregnancy category C
- Drug should be given only if benefit justifies risk to fetus
- Not adequately evaluated in nursing mothers
Precautions & Warnings
- Adrenocortical insufficiency may persist after therapy discontinuation
- Enhanced effect on patients with hypothyroidism and cirrhosis
- Cautious use in patients with ocular herpes simplex
- Monitor growth and development of infants and children on prolonged therapy
Overdose Effects
- Rare reports of acute toxicity and death following overdose
- Supportive and symptomatic treatment
- Monitor serum electrolytes
Therapeutic Class
- Glucocorticoids
Storage Conditions
- Store in cool, dry place away from light
- Keep out of reach of children