Medrol 16 mg (Tablet)

Unit Price: ৳ 23.45 (1 x 14: ৳ 328.30)

Strip Price: ৳ 328.30

Medicine Details

Category	Details
Generic	Methylprednisolone
Company	Pfizer
Also available as	Medrol 4 mg tablet

Indications

Endocrine Disorders
Rheumatic Disorders
Collagen Diseases
Dermatologic Diseases
Allergy
Ophthalmic Diseases
Respiratory Diseases
Hematological Disorders
Neoplastic Diseases
Edematous States
Gastrointestinal Disease
CNS Disease

Description

Medrol is a potent anti-inflammatory steroid with greater anti-inflammatory potency than Prednisolone and less tendency to induce sodium and water retention. It has a relative potency of at least four to one to Hydrocortisone.

Pharmacology

Pharmacodynamic properties: Methylprednisolone is a potent anti-inflammatory agent that profoundly inhibits the immune system. It primarily binds to and activates intracellular glucocorticoid receptors, influencing various bodily systems.
Pharmacokinetic properties: Methylprednisolone is rapidly absorbed with high bioavailability following oral administration. It is widely distributed into tissues, crosses the blood-brain barrier and placental barrier, and is metabolized in the liver.

Dosage & Administration

Usual range: 2-48 mg daily in divided doses
Anti-inflammatory or immunosuppressive initial dosage: Varies from 4-48 mg per day depending on specific disease entity
Anti-inflammatory or immunosuppressive maintenance dosage: Determined by decreasing initial dosage in small decrements until adequate clinical response is reached
Multiple Sclerosis treatment: Daily doses of 160 mg for a week followed by 64 mg every other day for 1 month
Alternate-day therapy (ADT): Considered for patients requiring long-term treatment

Interaction

Erythromycin inhibits metabolism of Medrol
Estrogens can increase the effect of corticosteroids by 50%
Cyclosporin reduces the metabolism of Medrol
Medrol may increase or decrease the effect of blood thinners

Contraindications

Contraindicated in systemic fungal infections and known hypersensitivity to components

Side Effects

Fluid retention
Weight gain
High blood pressure
Potassium loss
Headache
Muscle weakness
Glaucoma
Cataracts
Peptic ulceration
Growth retardation in children
Psychic disturbances

Pregnancy & Lactation

Pregnancy category C; should be used only if potential benefit justifies potential risk to the fetus

Precautions & Warnings

Adrenocortical insufficiency may persist for months after discontinuation of therapy
Enhanced effect of corticosteroids on patients with hypothyroidism
Corticosteroids should be used cautiously in patients with ocular herpes simplex
Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia

Overdose Effects

Report of acute toxicity rare and there is no specific antidote available; treatment is supportive and symptomatic