Minipress XL 5 mg (Tablet (Extended Release))

Unit Price: ৳ 21.18 (2 x 15: ৳ 635.40)
Strip Price: ৳ 317.70

Medicine Details

Category Details
Generic Prazosin hydrochloride
Company Pfizer
Also available as

Indications

  • Treatment of essential (primary) hypertension
  • Treatment of secondary hypertension
  • Treatment of left ventricular failure
  • Treatment of Raynaud's phenomenon and Raynaud's disease
  • Adjunct in the symptomatic treatment of urinary obstruction caused by benign prostatic hyperplasia

Pharmacology

  • Causes decrease in total peripheral vascular resistance
  • Selective inhibition of postsynaptic alpha-1-adrenoreceptors in vascular smooth muscle
  • Blood pressure lowering in supine and standing positions
  • Reduction in left ventricular filling pressure
  • Reduction in cardiac impedance
  • Improves urinary pressure profile in men

Dosage & Administration

  • Therapy initiated with a low starting dose
  • Dosage adjusted according to the patient's individual toleration
  • Maintenance dosage given as a twice or three times daily regimen
  • Recommended starting dosage for left ventricular failure
  • Use daily maintenance dosage for left ventricular failure
  • Recommended starting dosage for Raynaud's phenomenon and Raynaud's disease
  • Usual daily maintenance dosage for Raynaud's phenomenon and Raynaud's disease
  • Recommended starting dose for benign prostatic hyperplasia
  • Recommended starting dose for Prazosin XR Extended-Release Tablets
  • Maintenance dose for Prazosin XR Extended-Release Tablets
  • Patients controlled on Prazosin Tablets alone or in combination with other antihypertensive medications may be switched to Prazosin XR Extended Release Tablets

Interaction

  • No adverse drug interaction observed in clinical experience
  • Administered without adverse drug interaction with cardiac-glycosides, hypoglycemic agents, tranquilizers and sedatives, antiarrhythmic agents, analgesic, antipyretic, and anti-inflammatory agents

Contraindications

  • Contraindicated in patients with known sensitivity to quinazolines

Side Effects

  • Common reactions include dizziness, headache, drowsiness, lack of energy, weakness, palpitations, and nausea
  • Other reactions associated with Minipress XL therapy
  • Nervousness, vertigo, hallucinations, depression, rash, urinary frequency, impotence, incontinence, priapism, blurred vision, dry mouth, fever, arthralgia

Pregnancy & Lactation

  • No teratogenic effects seen in animal testing
  • Safety of Prazosin use during pregnancy not yet established
  • Excreted in small amounts in human milk

Precautions & Warnings

  • Postural hypotension reported with the commencement of therapy
  • Recommendation for careful monitoring of blood pressure
  • Left ventricular failure patients may experience a clinical efficacy diminishment after several months of treatment

Use in Special Populations

  • Not recommended for the treatment of children under the age of 12 years
  • Not recommended for left ventricular failure due to mechanical obstruction
  • Adequate data not yet available for left ventricular failure due to a recent myocardial infarction

Overdose Effects

  • Accidental ingestion of at least 50 mg of Minipress XL in a two-year child resulted in profound drowsiness and depressed reflexes
  • No decrease in blood pressure was noted

Therapeutic Class

  • Alpha adrenoceptor blocking drugs

Storage Conditions

  • Store below 30°C
  • Keep away from light and moisture
  • Keep away from reach out of the children

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