Barinez 2 mg (Tablet)

Indications

• Treatment of adult patients with moderate to severely active Rheumatoid Arthritis
• Inadequate response to one or more tumor necrosis factor (TNF) antagonist therapies

Pharmacology

• Selective and reversible inhibitor of Janus kinase JAK1 and JAK2
• Transduction of intracellular signals from cell surface receptors for cytokines and growth factors
• Involvement in haematopoiesis, inflammation, and immune function
• Reduction of phosphorylation and activation of signal transducers and activators of transcription (STATs)

Dosage & Administration

• Recommended adult dose of 2 mg once daily
• May be used as monotherapy or in combination with Methotrexate or other Disease-modifying antirheumatic drugs (DMARDS)
• Can be given orally with or without food
• Safety and effectiveness in pediatric patients not established
• Dose adjustment for elderly patients with decreased renal function
• No dose adjustment in patients with mild or moderate hepatic impairment
• Not recommended for use in patients with estimated GFR of less than 60 mL/min/I .73 m2

Interaction

• Increased exposure when co-administered with strong OAT3 inhibitors (e.g., probenecid)
• Not studied in combination with other JAK inhibitors or with biologic DMARDS

Contraindications

• Avoid initiation or interrupt in patients with hemoglobin less than 8 g/dL
• Avoid initiation or interrupt in patients with an Absolute Lymphocyte Count less than 500 cells/mm3
• Avoid initiation or interrupt in patients with an Absolute Neutrophil Count less than 1000 cells/mm3

Side Effects

• Most commonly reported adverse drug reactions: increased LDL cholesterol, upper respiratory tract infections, nausea

Pregnancy & Lactation

• Contraindicated during pregnancy
• No information available on the presence in human milk

Precautions & Warnings

• Avoid use in patients with an active, serious infection, including localized infections
• Not to be given to patients with active TB
• Consider risks and benefits prior to initiating therapy in patients with a known malignancy
• Use with caution in patients at increased risk of thrombosis
• Use with caution in patients at increased risk for gastrointestinal perforation
• To be dispensed only by the prescription of a registered physician

Overdose Effects

• Patient should be monitored for signs and symptoms of adverse reactions
• Patients who develop adverse reactions should receive appropriate treatment

Therapeutic Class

• Immunosuppressant

Storage Conditions

• Store at or below 30°C temperature
• Keep away from light and wet place
• Keep out of reach of children

Related Brands

• Baricit 2 mg (Tablet) - delta-pharma-ltd