Uritone 40 mg+50 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Furosemide spironolactone
Company Renata limited
Also available as
Uritone 20 mg tablet

Indications

  • Essential hypertension
  • Chronic congestive heart failure
  • Hepatic cirrhosis
  • Swelling due to excess fluid retention
  • Hyperaldosteronism
  • Resistant edema associated with secondary hyperaldosteronism

Pharmacology

  • Complementary mechanisms of spironolactone and furosemide
  • Additive or synergistic diuretic effect
  • Inhibition of Na+/K+/2Cl- co-transporter
  • Blockage of reabsorption of sodium, potassium, and chloride ions
  • Potassium loss
  • Inhibition of aldosterone action
  • Increased sodium excretion
  • Reduced potassium loss induced by furosemide

Dosage & Administration

  • 1 to 4 tablets daily of furosemide 20 and spironolactone 50 mg
  • 1 to 2 tablets daily of furosemide 40 and spironolactone 50 mg for stabilized patients requiring higher dosage
  • Not suitable for use in children
  • Slower excretion in the elderly

Interaction

  • Increased risk of hyperkalemia with ACE inhibitors or potassium salts
  • Elevated levels of cardiac glycosides such as digoxin in the blood
  • Possible digitalis toxicity
  • Hypokalemia with corticosteroids
  • Reduced or abolished effects when used with indomethacin and possibly other NSAIDs
  • Increased ototoxicity of aminoglycoside antibiotics
  • Reduced natriuretic and anti-hypertensive effect with simultaneous use of sucralfate

Contraindications

  • Anuria
  • Acute renal insufficiency
  • Severe impairment of renal function
  • Hyperkalemia
  • Addison's disease
  • Hypersensitivity to spironolactone, furosemide, or sulphonamides

Side Effects

  • Headache
  • Drowsiness
  • Gastrointestinal distress
  • Ataxia
  • Mental confusion
  • Skin rashes
  • Gynaecomastia
  • Breast enlargement
  • Hirsutism
  • Deepening of the voice
  • Menstrual irregularities
  • Impotence
  • Increase in blood-urea-nitrogen concentrations
  • Mild acidosis
  • Hyponatremia
  • Excessive diuresis leading to dehydration
  • Reduction in blood volume
  • Cardiac arrhythmias
  • Thrombosis
  • Embolism

Pregnancy & Lactation

  • Crossing the placental barrier
  • Possible fetal abnormalities
  • Need for careful assessment of benefit versus hazards in pregnant women
  • Detection of metabolites in breast milk
  • Consideration of alternative feeding method if essential use of spironolactone is required
  • Excretion in breast milk
  • Discontinuation of breastfeeding if essential to use furosemide

Precautions & Warnings

  • Caution in patients liable to electrolyte deficiency
  • Use with caution in diabetes, enlarged prostate, hypotension, hypovolemia

Therapeutic Class

  • Potassium-sparing diuretics
  • Aldosterone antagonists

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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