Doxolar 400 mg (Tablet)

Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Doxophylline
Company Kumudini pharma ltd
Also available as
Doxolar 200 mg tablet

Product Information

  • Title:
    • Doxolar Bronchodilator
    • Methyl Xanthine Derivative
  • Categories:
    • Medicine
    • Pharmaceutical
  • Description: Doxolar is a bronchodilator used to treat bronchial asthma, bronchospasm, chronic obstructive pulmonary disease (COPD), and pulmonary disease with spastic bronchial component. It contains Doxophylline, a novel bronchodilator that selectively inhibits phosphodiesterase 4, relaxes bronchial smooth muscle, and appears to have decreased affinities toward adenosine A1 and A2 receptors.

Attributes

  • Indications:
    • Bronchial asthma
    • Bronchospasm
    • Chronic obstructive pulmonary disease (COPD)
    • Spastic bronchial component
  • Pharmacology:
    • Selective inhibition of phosphodiesterase 4
    • Relaxation of bronchial smooth muscle
    • Decreased affinities toward adenosine A1 and A2 receptors
    • Inhibition of platelet activating factor (PAF) and leukotriene production
  • Dosage and Administration:
    • Elderly: 200 mg tablet two or three times daily
    • Adults: 400 mg tablet two or three times daily
    • Children (>12 years): 10 ml syrup or 200 mg tablet two or three times daily
    • Children (6-12 years): 6-9 mg/kg body weight two times daily
    • Doxophylline SR tablet for required daily dose of 400 mg
    • Dosage should be as prescribed by the physician
  • Interaction:
    • Contraindicated with other xanthine preparations
    • Limit consumption of caffeine-containing beverages and food
    • Caution with ephedrine or other sympathomimetic drugs
    • Concurrent administration may affect hepatic clearance
    • Some drugs may reduce hepatic clearance while others may increase it
  • Contraindications:
    • Known hypersensitivity to the drug or other xanthine derivatives
    • Acute myocardial infarction
    • Hypotension
    • Lactation
  • Side Effects:
    • Nausea
    • Vomiting
    • Epigastric pain
    • Headache
    • Irritability
    • Insomnia
    • Tachycardia
    • Extrasystoles
    • Tachypnea
    • Hyperglycemia
    • Albuminuria
    • Severe cardiac arrhythmias (in case of overdose)
    • Tonic-clonic seizure (in case of overdose)
  • Pregnancy and Lactation:
    • Caution during pregnancy with evaluation of risk-benefit ratio
    • Contraindicated during lactation
    • No sufficient clinical evidence about effects during pregnancy
    • Animal tests have shown no interference with pre and postnatal growth
  • Precautions and Warnings:
    • Factors reducing hepatic clearance may increase plasma levels
    • Monitoring of blood levels recommended in certain cases
    • Caution in patients with cardiac disease, hypertension, hypoxemia, hyperthyroidism, liver disease, renal impairment
    • No risk of addiction or dependence
  • Overdose Effects:
    • Severe cardiac arrhythmias
    • Tonic-clonic seizure
    • Symptomatic treatment of cardiovascular collapse in case of overdose
    • No specific antidote for overdose
  • Therapeutic Class:
    • Bronchodilator
    • Methyl xanthine derivative
  • Storage Conditions:
    • Keep in a dry place away from light and heat
    • Keep out of the reach of children
    • Use only on prescription of specialist physician

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