G-Thiazide T 25 mg+50 mg (Tablet)
Unit Price: ৳ 0.50 (10 x 10: ৳ 50.00)
Strip Price: ৳ 5.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Hydrochlorothiazide triamterene |
| Company | Gonoshasthaya pharma ltd |
Indications
- Treats high blood pressure
- Prevents strokes, heart attacks, and kidney problems
- Combination of diuretics
- Used for low potassium levels
- Reduces edema caused by heart failure, liver disease, or kidney disease
Pharmacology
- Triamterene inhibits Na for K exchange
- Hydrochlorothiazide increases excretion of Na and water
- Thiazides affect renal tubular mechanisms
- Reduces plasma volume and increases renin activity
- Co-administration with ACE inhibitor
Dosage
- Initial dosage for hypertension and oedema
- Adjust dosage according to response
- Maintenance dosage for oedema
- Maximum daily dosage
Administration
- Oral administration once daily
- Take with or without food
- Avoid close to bedtime
- Consideration with cholesterol-lowering drugs
- Dosage based on medical condition and response
Interaction
- Reduces renal clearance of lithium
- Antagonizes diuretic effect with certain drugs
- Enhanced effect with other hypotensive agents
- May decrease arterial responsiveness to norepinephrine
- Increases responsiveness to tubocurarine
- Risk of acute renal failure with certain drugs
- Increased risk of hyperkalaemia with certain drugs
- Increased risk of ototoxicity and nephrotoxicity with platinum compounds
Contraindications
- Hyperkalaemia (≥5.5 mEq/L)
- Diabetic ketoacidosis
- Addison's disease
- Progressive renal failure
- Increasing hepatic dysfunction
- Concomitant use with certain drugs
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Dizziness
- Weakness
- Hypotension
- Headache
- Muscle cramps
- Dry mouth
- Thirst
- Anaphylaxis
- Rash
- Metabolic acidosis
- Pancreatitis
- SLE and photosensitivity (Rare)
Pregnancy & Lactation
- Category C: Potential benefit justifies potential risk to the foetus
Precautions & Warnings
- Patients with prediabetes or DM
- Diabetic nephropathy
- Predisposition to gout
- History of renal lithiasis
- Hepatic or renal impairment
- Pregnancy and lactation
Overdose Effects
- Electrolyte imbalance
- Nausea
- Vomiting
- Weakness
- Polyuria
- Lassitude
- Fever
- Flushed face
- Hypotension
- Cardiac arrhythmias
- Management: Induce immediate evacuation through emesis or gastric lavage
- Pressor agents e.g. norepinephrine may be given in case of hypotension
Therapeutic Class
- Combined antihypertensive preparations
Storage Conditions
- Store between 20-25°C
- Protect from light