Natfol 5 mg (Tablet)
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Folinic acid |
| Company | Somatec pharmaceuticals ltd |
Indications
- Neutralising the immediate toxic effects of folic acid antagonists, e.g. Methotrexate
- Calcium folinate rescue- a treatment technique to minimise systemic toxicity
- Treatment of megaloblastic anaemias due to various causes
Composition
- Calcium Folinate Hydrate BP 6.249 mg equivalent to Folinic Acid 5 mg
- Calcium Folinate Hydrate BP 18.746 mg equivalent to Folinic Acid 15 mg
Pharmacology
- Calcium Folinate Hydrate is the calcium salt of folinic acid
- Folinic acid is involved as a cofactor for 1-carbon transfer reactions in the biosynthesis of nucleic acids
- Potent antidote for hematopoietic and reticuloendothelial toxic effects of folic acid antagonists
Dosage & Administration
- Calcium folinate rescue should begin as soon as possible after an inadvertent overdose of methotrexate
- Dosage regimens vary depending upon the dose of methotrexate administered
Interaction
- Caution is required during concurrent administration of calcium folinate with fluoropyrimidine
- Folinates given in large amounts may counteract the antiepileptic effect of certain medications
Contraindications
- Contraindicated in patients with known hypersensitivity to calcium folinate or any other components of this product
- Contraindicated in pernicious anemia or other megaloblastic anemia where vitamin B12 is deficient
Side Effects
- Mucositis
- Stomatitis
- Leukopenia
- Diarrhea
Pregnancy & Lactation
- No well-controlled clinical studies in pregnant women
- Caution should be exercised when calcium folinate is administered to a nursing mother
Precautions & Warnings
- Should only be used with methotrexate or 5-FU under the direct supervision of a clinician experienced in the use of cancer chemotherapeutic agents
- Folinic acid should not be given simultaneously with folic acid antagonists, e.g. Methotrexate
Overdose Effects
- Excessive amounts of calcium folinate may nullify the chemotherapeutic effect of folic acid antagonists
- No specific antidote to calcium folinate overdose
Therapeutic Class
- Supportive Care Therapy
Storage Conditions
- Do not store above 30°C
- Keep away from light and out of the reach of children