Baritor 2 mg (Tablet)

Unit Price: ৳ 25.00 (2 x 10: ৳ 500.00)
Strip Price: ৳ 250.00

Medicine Details

Category Details
Generic Baricitinib
Company Square pharmaceuticals plc

Indications

  • Treatment of moderate to severely active Rheumatoid Arthritis
  • Inadequate response to tumor necrosis factor (TNF) antagonist therapies

Pharmacology

  • Selective and reversible inhibitor of Janus kinase JAK1 and JAK2
  • Inhibition of intracellular signals from cell surface receptors
  • Modulation of signaling pathways

Dosage & Administration

  • Recommended adult dose of 2 mg once daily
  • Monotherapy or in combination with Methotrexate or other DMARDs
  • Oral administration with or without food
  • Safety and effectiveness not established in pediatric patients
  • Dose selection considerations for elderly patients with decreased renal function
  • No dose adjustment necessary in mild or moderate hepatic impairment
  • Not recommended for patients with estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m2

Interaction

  • Increased exposure when co-administered with strong OAT3 inhibitors
  • Not studied in combination with other JAK inhibitors or with biologic DMARDs

Contraindications

  • Anemia with hemoglobin less than 8 g/dL
  • Lymphopenia with Absolute Lymphocyte Count less than 500 cells/mm3
  • Neutropenia with Absolute Neutrophil Count less than 1000 cells/mm3

Side Effects

  • Common adverse reactions include increased LDL cholesterol, upper respiratory tract infections, and nausea

Pregnancy & Lactation

  • Contraindicated during pregnancy
  • No information available on the presence of Baricitinib in human milk

Precautions & Warnings

  • Avoid use in patients with active, serious infection
  • Avoid use in patients with active tuberculosis
  • Consider risks and benefits in patients with known malignancy or lymphoproliferative disorders
  • Use with caution in patients at increased risk of thrombosis or gastrointestinal perforation
  • To be dispensed only by the prescription of a registered physician

Overdose Effects

  • Monitoring for signs and symptoms of adverse reactions in case of overdose
  • Appropriate treatment for patients who develop adverse reactions

Therapeutic Class

  • Immunosuppressant

Storage Conditions

  • Store at or below 30°C temperature
  • Keep away from light and wet place
  • Keep out of reach of children

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