Secrin M 2 mg+500 mg (Tablet (Extended Release))

Unit Price: ৳ 12.00 (7 x 4: ৳ 336.00)
Strip Price: ৳ 48.00

Medicine Details

Category Details
Generic Glimepiride metformin
Company Square pharmaceuticals plc
Also available as
Secrin m 1 mg tablet

Indications

  • Adjunct to diet and exercise in type 2 diabetes mellitus patients
  • Monotherapy with glimepiride or metformin does not result in adequate glycemic control
  • Replacement of combination therapy of glimepiride and metformin

Pharmacology

  • Decreases blood glucose concentration
  • Stimulates release of insulin from pancreatic beta cells
  • Improves sensitivity of beta cells to glucose stimulus
  • Reduces basal hepatic glucose production
  • Increases peripheral tissue sensitivity to insulin
  • Improves glucose uptake
  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity
  • Substrate for transporters OCT1 and OCT2

Dosage

  • Governed by the desired blood glucose level
  • Must be lowest sufficient to achieve desired metabolic control
  • Glucose levels in blood and urine must be measured regularly
  • Do not correct mistakes by taking a larger dose
  • Glimepiride requirements may fall as treatment proceeds
  • The highest recommended dose per day
  • Starting dose should not exceed daily doses of glimepiride or metformin already being taken
  • When switching from combination therapy, administer on basis of current dosage

Administration

  • Must be swallowed whole
  • Not crushed or chewed

Interaction

  • Metabolized by cytochrome P450 2C9 (CYP2C9)
  • Potentiation and hypoglycemia with certain drugs
  • Weakening and raised blood glucose levels with certain drugs
  • May interact with alcohol
  • Bile acid sequestrant reduces absorption

Contraindications

  • Hypersensitivity to glimepiride, metformin, or any excipients
  • Pregnant women
  • Breastfeeding women
  • Severe impairment of liver function
  • Dialysis patients
  • Hypersensitivity to metformin or excipients
  • Acute metabolic acidosis
  • Severe renal failure or dysfunction
  • Acute conditions altering renal function
  • Conditions causing tissue hypoxia
  • Hepatic insufficiency
  • Acute alcohol intoxication
  • Lactation

Side Effects

  • Hypoglycemia
  • Visual impairment
  • Gastrointestinal symptoms
  • Hepatitis, liver enzyme elevation
  • Blood picture changes
  • Alopecia
  • Allergic or pseudo allergic reactions
  • Weight gain
  • Gastrointestinal symptoms
  • Metallic taste
  • Decrease of vitamin B12 absorption
  • Lactic acidosis
  • Hemolytic anemia
  • Reduction of thyrotropin level
  • Hypomagnesemia
  • Encephalopathy
  • Photosensitivity
  • Liver function tests abnormalities

Pregnancy & Lactation

  • Glimepiride not to be taken during pregnancy
  • Metformin not recommended for pregnancy
  • Glimepiride not for breastfeeding women
  • Metformin excreted into milk, decision should be made

Precautions & Warnings

  • Risk of hypoglycemia in initial weeks of treatment
  • Increased risk in presence of hypoglycemia risk factors
  • Severe hypoglycemia requires immediate treatment
  • G6PD-deficiency caution
  • Regular monitoring of TSH levels in hypothyroidism
  • Long-term treatment associated with decrease in vitamin B12 levels

Use in Special Populations

  • Insufficient data for pediatric use
  • Assessment of GFR before initiation of treatment
  • Maximum daily dose in relation to declining renal function

Overdose Effects

  • Severe life-threatening hypoglycemia
  • Lactic acidosis
  • Pancreatitis

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Store cool and dry
  • Protected from light

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