Ofmit 8 mg/4 ml (IM/IV Injection)

4 ml ampoule: ৳ 30.00 (2 x 5: ৳ 300.00)

Medicine Details

Category Details
Generic Ondansetron
Company Nuvista pharma ltd
Also available as
Ofmit 8 mg tablet

Indications

  • Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
  • Prevention and treatment of post-operative nausea and vomiting
  • Prevention of radiotherapy-induced nausea and vomiting

Product Formulation

  • Oral soluble film

Dosage Form

  • Tablet
  • Orodispersible tablet
  • Injection
  • Oral Solution

Active Ingredient

  • Ofmit base

Chemical Formula

  • C18H19N3O

Recommended Dosage for Adults

  • 8 mg tablet: Three 0.15 mg/kg doses, up to a maximum of 16 mg per dose
  • 4 mg orodispersible tablet: Three 0.15 mg/kg doses, up to a maximum of 16 mg per dose
  • Injection: Three 0.15 mg/kg doses, up to a maximum of 16 mg per dose, infused intravenously over 15 minutes

Administration Instructions

  • Tear the pouch carefully along with the edge tear mark
  • Place the film on top of the tongue allowing it to dissolve within 20 seconds
  • Do not chew or swallow the film whole
  • Swallow after the film dissolves, with or without liquid
  • Wash hands after administration

Interaction with Cytochrome P-450 Enzyme

  • Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes which may be affected by inducers or inhibitors

Contraindications

  • Hypersensitivity to the drug or its components
  • Concomitant use of apomorphine

Common Side Effects

  • Headache
  • Constipation
  • Diarrhea
  • Rash
  • Flushing or warmth sensation
  • Hiccups
  • Liver enzyme abnormalities

Rare Side Effects

  • Anaphylaxis
  • Brochospasm
  • Tachycardia
  • Angina
  • Hypokalemia
  • Shortness of breath

Pregnancy & Lactation Concerns

  • No evidence of impaired fertility or harm to the fetus in animal studies
  • Excreted in breast milk, caution advised during nursing

Precautions

  • Hypersensitivity reactions may occur
  • Not to be used in place of nasogastric suction
  • May mask progressive ileus and/or gastric distension

Dosage Adjustment in Special Populations

  • Renal function: same as for general population
  • Hepatic impairment: single maximal daily dose of 8 mg

Therapeutic Class

  • Anti-emetic drugs

Storage Conditions

  • Store at temperature not exceeding 30°C in a dry place
  • Protect from light and moisture

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