Easybak 10 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Baclofen |
| Company | Euro pharma ltd |
Indications
- spasticity resulting from multiple sclerosis
- flexor spasms and concomitant pain
- clonus and muscular rigidity
- skeletal muscle spasm resulting from rheumatic disorders
- spinal cord injuries and other spinal cord diseases
- cerebrovascular accidents or neoplastic or degenerative brain disease
Pharmacology
Baclofen inhibits both monosynaptic and polysynaptic reflexes at the spinal level by stimulating the GABAB receptors, which inhibits the release of glutamate and aspartate. It may also act at intraspinal sites producing CNS depression. Baclofen also exerts an antinociceptive effect.
Dosage & Administration
Adult & children over 10 years: 5 mg 3 times daily, max. 100 mg daily. Children <10 years: Treatment is usually started with 2.5 mg given 4 times daily then raised according to requirement.
Interaction
- Increased sedation may occur if taken with agents acting on the central nervous system
- Combined treatment with antihypertensives is likely to increase the fall in blood pressure
- The concomitant administration of Easybak and tricyclic antidepressants may potentiate the pharmacological effects
- In patients with Parkinson's disease receiving treatment with Easybak and levodopa and carbidopa, there have been several reports of mental confusion, hallucinations, headaches, nausea and agitation
- The concurrent use of MAO inhibitors and Easybak may result in increased CNS depressant effects
- Caution should be exercised when administering Easybak and magnesium sulphate or other neuromuscular blocking agents since a synergistic effect may theoretically occur
Contraindications
Baclofen is contraindicated in patients with hypersensitivity to any component of this product.
Side Effects
- Transient drowsiness
- daytime sedation
- dizziness
- weakness
- fatigue
- Headache
- insomnia
- euphoria
- excitement
- depression
- confusion
- hallucinations
- paraesthesia
- nightmares
- muscle pain
- tinnitus
- slurred speech
Pregnancy & Lactation
Pregnancy category B3. Safe use of Baclofen during pregnancy has not been established. Baclofen crosses the placental barrier. Baclofen is excreted in breast milk however evidence to date suggests that the quantities are so small that no undesirable effects on the infant would be expected.
Precautions & Warnings
- Lower doses should be used for patients with impaired renal function or those undergoing chronic haemodialysis
- Patients suffering from not only spasticity but also from psychotic disorders, schizophrenia, depressive or manic disorders or confusional states should be treated cautiously and closely monitored
- In patients with epilepsy and muscle spasticity, Easybak may be used under appropriate supervision and provided that adequate anticonvulsive therapy is continued
Overdose Effects
Gastric lavage is important in case of severe overdose.
Therapeutic Class
Centrally acting Skeletal Muscle Relaxants
Storage Conditions
Keep below 30°C temperature, away from light & moisture, and out of the reach of children.