Informet LA 1000 mg (Long Acting Tablet)
Unit Price: ৳ 8.00 (6 x 10: ৳ 480.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Therapeutic Class
- Biguanides
Indications
- Treatment of type 2 diabetes mellitus in overweight adults
- Treatment of type 2 diabetes mellitus in overweight children and adolescents
- Reduction of diabetic complications in overweight type 2 diabetic adult patients treated with metformin as first-line therapy after diet failure
Pharmacology
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses for adults and children
- Usual starting dose for adults and children
- Recommended dosage increases and frequency
- Guidelines for Metformin extended release tablet
- Special dosage considerations for renal impaired patients
Interaction
- No information on chronic co-administration with Furosemide
- Nifedipine enhances absorption of Informet LA
- Minimal effects of Informet LA on Nifedipine
- Potential interaction with cationic drugs eliminated by renal tubular secretion
- No effect on Cimetidine pharmacokinetics
- Drugs that may produce hyperglycemia and impact glycemic control
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis or severe renal failure
- Acute conditions with potential to alter renal function
- Acute or chronic diseases causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decreased vitamin B12 absorption
- Cases of peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite
- Liver function test abnormalities or hepatitis
- Skin reactions such as erythema, pruritus, urticaria
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Recommendation to use insulin instead of metformin during pregnancy
- Metformin excreted into human breast milk
- No adverse effects observed in breastfed newborns/infants
- Breastfeeding not recommended during metformin treatment
Precautions & Warnings
- Substantial excretion of Informet LA by the kidney
- Increased risk of lactic acidosis with impaired renal function
- Lowered vitamin B12 levels
- Risk of hypoglycemia when used in combination with insulin or insulin secretagogue
- Regular monitoring of renal function advised
- Need for Informet LA therapy adjustment before surgery or clinical investigations
- Use not advised in conditions causing dehydration or in patients suffering from serious infections or trauma
- Annual estimation of Vitamin B-12 levels for patients on continuous Informet LA therapy
- Blood glucose monitoring when in combination with a sulphonylurea
- Potential interaction between Informet LA and anticoagulants
Use in Special Populations
- Recommendation for metformin dosage adjustment based on renal function in elderly subjects
- No effect of metformin on growth and puberty detected during controlled clinical studies
- Careful follow-up of metformin effect on children's growth and puberty recommended
- Particular caution recommended when prescribing to children aged between 10 and 12 years
- Regular assessment of renal function and GFR
- Exercise special caution in situations where renal function may become impaired
Overdose Effects
- Hypoglycemia not seen with Informet LA doses up to 85g
- Occurrence of lactic acidosis in such circumstances
- Lactic acidosis as a medical emergency requiring treatment in hospital
- Hemodialysis as the most effective method to remove lactate and Informet LA
Storage Conditions
- Keep below 30°C temperature
- Protect from light & moisture
- Keep out of the reach of children