Informet LA 1000 mg (Long Acting Tablet)

Unit Price: ৳ 8.00 (6 x 10: ৳ 480.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Beximco pharmaceuticals ltd
Also available as
Informet 500 mg tablet Informet 850 mg tablet Informet la 500 mg tablet Informet la 750 mg tablet Informet xr 500 mg tablet Informet xr 750 mg tablet

Therapeutic Class

  • Biguanides

Indications

  • Treatment of type 2 diabetes mellitus in overweight adults
  • Treatment of type 2 diabetes mellitus in overweight children and adolescents
  • Reduction of diabetic complications in overweight type 2 diabetic adult patients treated with metformin as first-line therapy after diet failure

Pharmacology

  • Lowers basal and postprandial plasma glucose
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Maximum recommended daily doses for adults and children
  • Usual starting dose for adults and children
  • Recommended dosage increases and frequency
  • Guidelines for Metformin extended release tablet
  • Special dosage considerations for renal impaired patients

Interaction

  • No information on chronic co-administration with Furosemide
  • Nifedipine enhances absorption of Informet LA
  • Minimal effects of Informet LA on Nifedipine
  • Potential interaction with cationic drugs eliminated by renal tubular secretion
  • No effect on Cimetidine pharmacokinetics
  • Drugs that may produce hyperglycemia and impact glycemic control

Contraindications

  • Hypersensitivity to active substance or excipients
  • Acute metabolic acidosis or severe renal failure
  • Acute conditions with potential to alter renal function
  • Acute or chronic diseases causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decreased vitamin B12 absorption
  • Cases of peripheral neuropathy in patients with vitamin B12 deficiency
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite
  • Liver function test abnormalities or hepatitis
  • Skin reactions such as erythema, pruritus, urticaria

Pregnancy & Lactation

  • Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
  • Recommendation to use insulin instead of metformin during pregnancy
  • Metformin excreted into human breast milk
  • No adverse effects observed in breastfed newborns/infants
  • Breastfeeding not recommended during metformin treatment

Precautions & Warnings

  • Substantial excretion of Informet LA by the kidney
  • Increased risk of lactic acidosis with impaired renal function
  • Lowered vitamin B12 levels
  • Risk of hypoglycemia when used in combination with insulin or insulin secretagogue
  • Regular monitoring of renal function advised
  • Need for Informet LA therapy adjustment before surgery or clinical investigations
  • Use not advised in conditions causing dehydration or in patients suffering from serious infections or trauma
  • Annual estimation of Vitamin B-12 levels for patients on continuous Informet LA therapy
  • Blood glucose monitoring when in combination with a sulphonylurea
  • Potential interaction between Informet LA and anticoagulants

Use in Special Populations

  • Recommendation for metformin dosage adjustment based on renal function in elderly subjects
  • No effect of metformin on growth and puberty detected during controlled clinical studies
  • Careful follow-up of metformin effect on children's growth and puberty recommended
  • Particular caution recommended when prescribing to children aged between 10 and 12 years
  • Regular assessment of renal function and GFR
  • Exercise special caution in situations where renal function may become impaired

Overdose Effects

  • Hypoglycemia not seen with Informet LA doses up to 85g
  • Occurrence of lactic acidosis in such circumstances
  • Lactic acidosis as a medical emergency requiring treatment in hospital
  • Hemodialysis as the most effective method to remove lactate and Informet LA

Storage Conditions

  • Keep below 30°C temperature
  • Protect from light & moisture
  • Keep out of the reach of children

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