Kinexa 10 mg (Tablet)
Unit Price: ৳ 25.00 (3 x 10: ৳ 750.00)
Strip Price: ৳ 250.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Rivaroxaban |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Prevention of atherothrombotic events after Acute Coronary Syndrome
- Reduction of risk of stroke and systemic embolism in nonvalvular atrial fibrillation
- Prophylaxis of deep vein thrombosis (DVT) and pulmonary embolism (PE) after knee or hip replacement surgery
Pharmacology
- Highly selective direct factor Xa inhibitor
- Interrupts the intrinsic and extrinsic pathway of the blood coagulation cascade
- Does not inhibit thrombin or affect platelets
Dosage & Administration
- Recommended dose of 2.5 mg twice daily with Aspirin
- Different dosages for nonvalvular atrial fibrillation, DVT, and PE
- May be taken with or without food
Interaction
- Avoid concomitant use with P-gp and CYP3A4 inhibitors
- Avoid co-administration with strong CYP3A4 inducers
- Increased risk of bleeding with usage of certain drugs
Contraindications
- Known hypersensitivity to Rivaroxaban or any of the excipients
- Active pathological bleeding
Side Effects
- Increased chance of bleeding
- Spinal or epidural hematoma
- Increased risk of stroke after discontinuation in nonvalvular atrial fibrillation
Pregnancy & Lactation
- Pregnancy category C drug
- No established dosing for pregnant or breastfeeding women
- Unknown excretion in human milk
Precautions & Warnings
- Risk of thrombotic events upon early discontinuation
- Risk of fatal bleeding in the presence of certain risk factors
- Monitoring for signs of neurological impairment in case of neuraxial anesthesia
Overdose Effects
- May lead to hemorrhage
- No specific antidote available
- Consideration of activated charcoal for overdose
Therapeutic Class
Oral Anti-coagulants
Storage Conditions
Store in a cool and dry place, protected from light