Pulfibro 534 mg (Tablet)
Unit Price: ৳ 80.00 (2 x 10: ৳ 1,600.00)
Strip Price: ৳ 800.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pirfenidone |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of mild to moderate Idiopathic Pulmonary Fibrosis (IPF) in adults
Pharmacology
- Anti-inflammatory
- Antioxidant
- Anti-fibrotic properties
- Improves lung function
- Reduces acute exacerbations in IPF patients
- Suppresses TGF-β1
- Downregulates pro-inflammatory cytokines
Dosage & Administration
- Oral administration with food
- Initial titration regimen
- Recommended daily dose
- Dose adjustments for gastrointestinal events
- Dose adjustments for photosensitivity reaction or rash
- Dose adjustments for hepatic function
- Treatment interruption guidelines
Interaction
- Moderate and strong CYP1A2 inhibitors increase systemic exposure
- Dosage adjustment with concomitant medications
- Reduced adverse reactions observed with food intake
Contraindications
- Hypersensitivity to active substance or excipients
- Concomitant use of fluvoxamine
- Severe hepatic impairment or end stage liver disease
- Severe renal impairment or end stage renal disease
Side Effects
- Common: nausea, rash, abdominal pain, upper respiratory tract infection, diarrhea, fatigue, headache, dyspepsia, dizziness, vomiting, anorexia, gastroesophageal reflux disease, sinusitis, insomnia, weight decrease, arthralgia
- Rare: photosensitivity reaction, decreased appetite, pruritus, asthenia, dysgeusia, non-cardiac chest pain
Pregnancy & Lactation
- Precautionary avoidance during pregnancy
- Unknown excretion in human milk
- Effects on fertility in animal studies
Precautions & Warnings
- Monitoring of liver enzymes
- Precautions for photosensitivity and rash
- Precautions for gastrointestinal disorders
Use in Special Populations
- Safety and efficacy in children & adolescents
- Hepatic impairment considerations
- Renal impairment considerations
- Impact of smoking on exposure
Overdose Effects
- Limited clinical experience with overdose
- Mild and transient adverse reactions observed in overdose cases
Therapeutic Class
- Immunosuppressant
Storage Conditions
- Cool and dry storage
- Protection from light and moisture
- Keep out of reach of children