Bisocor Plus 2.5 mg+6.25 mg (Tablet)

Unit Price: ৳ 6.02 (3 x 10: ৳ 180.60)
Strip Price: ৳ 60.20

Medicine Details

Category Details
Generic Bisoprolol fumarate hydrochlorothiazide
Company Square pharmaceuticals plc
Also available as
Bisocor plus 5 mg tablet

Indications

  • Treatment of hypertension

Pharmacology

  • Additive antihypertensive effects of Bisoprolol and Hydrochlorothiazide
  • Bisoprolol Fumarate is a β1-selective adrenoceptor blocking agent
  • Hydrochlorothiazide is a benzothiadiazine diuretic
  • Mechanisms of electrolyte reabsorption affected by thiazides

Dosage & Administration

  • Effective doses range for Bisoprolol (2.5 to 40 mg) and Hydrochlorothiazide (12.5 to 50 mg)
  • Initial therapy with one 2.5/6.25 mg tablet once daily
  • Subsequent titration at 14-day intervals
  • Maximum recommended dose of 20/12.5 mg once daily

Interaction

  • Potentiation of action of other antihypertensive agents
  • Avoid combination with other beta-blocking agents
  • Cautious use with myocardial depressants or inhibitors of AV conduction
  • Increased risk of bradycardia with concomitant use of digitalis glycosides and beta-blockers

Contraindications

  • Cardiogenic shock
  • Overt cardiac failure
  • Second or third degree AV block
  • Marked sinus bradycardia
  • Anuria
  • Hypersensitivity to either component or other sulfonamide-derived drugs

Side Effects

  • Fatigue
  • Dizziness
  • Headache
  • Bradycardia
  • Arrhythmia
  • Peripheral ischemia
  • Chest pain
  • Palpitations
  • Rhythm disturbances
  • Cold extremities
  • Claudication
  • Orthostatic hypotension
  • Diarrhoea
  • Constipation
  • Nausea
  • Dyspepsia
  • Rhinitis
  • Pharyngitis

Pregnancy & Lactation

  • Pregnancy Category C
  • Use only if benefit justifies risk to fetus
  • Thiazides excreted in human breast milk

Precautions & Warnings

  • Hyperuricemia or acute gout may be precipitated in certain patients
  • Warning signs of fluid and electrolyte imbalance
  • Hypokalemia may develop
  • Gradual withdrawal over a period of about 2 weeks

Overdose Effects

  • Signs of overdose: bradycardia, hypotension, lethargy
  • Severe overdoses may lead to delirium, coma, convulsions, and respiratory arrest
  • Acute loss of fluid and electrolytes
  • Cardiovascular, neuromuscular, gastrointestinal, renal symptoms

Therapeutic Class

  • Combined antihypertensive preparations

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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