Dilitus 300 mcg (Tablet)

Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Voglibose
Company General pharmaceuticals ltd
Also available as

Indications

  • Reduction in Post-Prandial Hyperglycaemia (PPHG)
  • Immunotherapy for non-insulin-dependent diabetes mellitus (NIDDM) patients
  • Combination therapy with other Oral Hypoglycaemic Agents (OHAs)
  • Prevention of onset of type 2 diabetes mellitus
  • Helpful in elderly patients and in those with hepatic dysfunction or mild to moderate renal impairments
  • Prevention of hypoglycaemia in patients with glycogen storage disease
  • Prevention of hypoglycaemic attacks in non-diabetic hyperinsulinemia
  • Use in steroid-induced diabetes mellitus

Description

  • Selective inhibition of α-glucosidase in the enteric canal
  • Delaying the digestion and absorption of carbohydrate
  • Suppressing sharp increase in post-prandial plasma glucose

Pharmacology

  • Competitive inhibition of alpha-glucosidase enzymes in the small intestines
  • Selective blockade of pancreatic alpha-amylase
  • Reduction in the rate of digestion of complex carbohydrates
  • Decreased absorption of glucose

Dosage & Administration

  • Orally administered in a single dose of 0.2 mg, 3 times a day
  • Dosage may be increased up to 0.3 mg if necessary
  • Caution in pediatric and geriatric populations
  • Close observation for blood sugar level and gastrointestinal symptoms in geriatric patients

Interaction

  • Cautious co-administration with antidiabetic drugs
  • Drugs enhancing the hypoglycaemic action
  • Drugs diminishing the hypoglycaemic action

Contraindications

  • Hypersensitivity to Voglibose or excipients
  • Diabetic ketoacidosis, diabetic pre-coma
  • Severe infection, serious trauma
  • Gastrointestinal obstruction or predisposition to it

Side Effects

  • Gastrointestinal discomfort
  • Hypoglycaemia
  • Digestive disturbances
  • Liver dysfunction
  • Jaundice
  • Numbness and edema
  • Visual disturbances
  • Malaise and weakness
  • Hyperkalemia
  • Pancreatic enzyme changes

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Exceedingly low levels in human milk

Precautions & Warnings

  • Careful administration in specific patient populations
  • Attention to hypoglycaemia in patients receiving other antidiabetic drugs
  • Caution with chronic intestinal disease and hepatic or renal dysfunction
  • Special attention to elderly patients

Use in Special Populations

  • Poorly absorbed after oral doses
  • Pharmacokinetic studies in renal failure not available

Overdose Effects

  • Transient increase in flatulence, diarrhoea, and abdominal discomfort
  • No serious systemic reactions expected

Therapeutic Class

  • Alpha-Glucosidase inhibitor

Storage Conditions

  • Cool and dry place
  • Protect from light

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