Dilitus 300 mcg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Voglibose |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Reduction in Post-Prandial Hyperglycaemia (PPHG)
- Immunotherapy for non-insulin-dependent diabetes mellitus (NIDDM) patients
- Combination therapy with other Oral Hypoglycaemic Agents (OHAs)
- Prevention of onset of type 2 diabetes mellitus
- Helpful in elderly patients and in those with hepatic dysfunction or mild to moderate renal impairments
- Prevention of hypoglycaemia in patients with glycogen storage disease
- Prevention of hypoglycaemic attacks in non-diabetic hyperinsulinemia
- Use in steroid-induced diabetes mellitus
Description
- Selective inhibition of α-glucosidase in the enteric canal
- Delaying the digestion and absorption of carbohydrate
- Suppressing sharp increase in post-prandial plasma glucose
Pharmacology
- Competitive inhibition of alpha-glucosidase enzymes in the small intestines
- Selective blockade of pancreatic alpha-amylase
- Reduction in the rate of digestion of complex carbohydrates
- Decreased absorption of glucose
Dosage & Administration
- Orally administered in a single dose of 0.2 mg, 3 times a day
- Dosage may be increased up to 0.3 mg if necessary
- Caution in pediatric and geriatric populations
- Close observation for blood sugar level and gastrointestinal symptoms in geriatric patients
Interaction
- Cautious co-administration with antidiabetic drugs
- Drugs enhancing the hypoglycaemic action
- Drugs diminishing the hypoglycaemic action
Contraindications
- Hypersensitivity to Voglibose or excipients
- Diabetic ketoacidosis, diabetic pre-coma
- Severe infection, serious trauma
- Gastrointestinal obstruction or predisposition to it
Side Effects
- Gastrointestinal discomfort
- Hypoglycaemia
- Digestive disturbances
- Liver dysfunction
- Jaundice
- Numbness and edema
- Visual disturbances
- Malaise and weakness
- Hyperkalemia
- Pancreatic enzyme changes
Pregnancy & Lactation
- Safety in pregnancy not established
- Exceedingly low levels in human milk
Precautions & Warnings
- Careful administration in specific patient populations
- Attention to hypoglycaemia in patients receiving other antidiabetic drugs
- Caution with chronic intestinal disease and hepatic or renal dysfunction
- Special attention to elderly patients
Use in Special Populations
- Poorly absorbed after oral doses
- Pharmacokinetic studies in renal failure not available
Overdose Effects
- Transient increase in flatulence, diarrhoea, and abdominal discomfort
- No serious systemic reactions expected
Therapeutic Class
- Alpha-Glucosidase inhibitor
Storage Conditions
- Cool and dry place
- Protect from light