Prupride 2 mg (Tablet)
Unit Price: ৳ 24.00 (3 x 10: ৳ 720.00)
Strip Price: ৳ 240.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Prucalopride succinate |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- Symptomatic treatment of chronic constipation in adults
Pharmacology
- Acts as a selective stimulator of the 5-HT4 receptors
- Stimulates motility by interacting specifically with 5-HT4 receptors in the GI tract
- Causes release of acetylcholine and further contraction of the muscle layer of the colon
Dosage & Administration
- Adults: 2 mg once daily with or without food
- Older people: Start with 1 mg once daily; if needed the dose can be increased to 2 mg once daily
- Children: Not indicated for use in children and adolescents younger than 18 years
Interaction
- Low interaction potential with therapeutic concentrations of Prupride
- May have interactions with potent inhibitors of P-gp such as verapamil, cyclosporine A and quinidine
Contraindications
- Hypersensitivity to the active substance or to any of the excipients
- Renal impairment requiring dialysis
Side Effects
- Frequently reported adverse reactions include headache and gastrointestinal symptoms
- Majority of adverse events were mild to moderate in intensity
Pregnancy & Lactation
- Not recommended during pregnancy
- Effective contraception should be used during treatment
- Not recommended during breastfeeding
Precautions & Warnings
- Renal excretion is the main route of elimination
- Caution in prescribing to patients with severe hepatic impairment
- Possible reduction in efficacy of oral contraceptives during severe diarrhea
Use in Special Populations
- Dose adjustment for patients with severe renal impairment
- Dose adjustment for patients with severe hepatic impairment
Overdose Effects
- May result in symptoms such as headache, nausea, and diarrhea
- Requires symptomatic and supportive treatment
Therapeutic Class
- Osmotic purgatives
Storage Conditions
- Store at room temperature, below 30°C
- Do not remove desiccant
- Dispense in original bottle