Prupride 1 mg (Tablet)
Unit Price: ৳ 14.00 (3 x 10: ৳ 420.00)
Strip Price: ৳ 140.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Prucalopride succinate |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- Symptomatic treatment of chronic constipation in adults
Pharmacology
- Selective stimulator of 5-HT4 receptors
- Stimulates motility in the gastrointestinal tract
- Causes release of acetylcholine
Dosage & Administration
- Adults: 2 mg once daily with or without food
- Older people: Start with 1 mg once daily
- Children: Not for use in children and adolescents under 18 years
Interactions
- Low interaction potential with CYP-mediated metabolism
- May be affected by potent inhibitors of P-gp
Contraindications
- Hypersensitivity to the active substance or excipients
- Renal impairment requiring dialysis
Side Effects
- Most frequent: headache, abdominal pain, nausea, diarrhea
- Adverse reactions occur predominantly at the start of therapy
Pregnancy & Lactation
- Not recommended during pregnancy
- Effective contraception advised during treatment
- Not recommended during breastfeeding based on animal studies
Precautions & Warnings
- Caution in severe renal impairment
- Caution in severe hepatic impairment
- Possible reduction in efficacy of oral contraceptives in case of severe diarrhea
Use in Special Populations
- Renal Impairment: Dose adjustment for severe impairment
- Hepatic Impairment: Dose adjustment for severe impairment
Overdose Effects
- May result in symptoms like headache, nausea, and diarrhea
- Supportive measures required for extensive fluid loss
Therapeutic Class
- Osmotic purgatives
Storage Conditions
- Store at room temperature below 30°C
- Dispense in original bottle with desiccant