Hexiphen 5 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct in the treatment of all forms of parkinsonism
- Useful as adjuvant therapy with levodopa
- Control of extrapyramidal disorders caused by CNS drugs
Description
- Exerts inhibitory effect on parasympathetic nervous system
- Relaxing effect on smooth musculature
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Higher affinity for central muscarinic receptors in the cerebral cortex
- Lower affinity for peripheral muscarinic receptors
Dosage & Administration
- Individualized dosage
- Initial dose should be low and increased gradually
- Postencephalitic patients may prefer taking it after meals
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with alcohol or other CNS depressants
- Intensification of anticholinergic effects with MAOIs and tricyclic antidepressants
Contraindications
- Hypersensitivity to Trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Psychiatric manifestations
- Cognitive dysfunctions
- Constipation
- Drowsiness
- Urinary hesitancy
- Tachycardia
- Pupil dilation
- Increased intraocular pressure
- Choreiform movements
- Weakness
- Vomiting
- Headache
- Exacerbation of parkinsonism with abrupt treatment withdrawal
- Neuroleptic malignant syndrome with abrupt treatment withdrawal
- Angle-closure glaucoma
- Sinus bradycardia
- Dry skin
- Cycloplegia
Pregnancy & Lactation
- Use during pregnancy when benefit outweighs risk
- Caution in nursing women
- Potential suppression of lactation
Precautions & Warnings
- Gonioscope evaluation prior to therapy
- Monitoring of intraocular pressures
- Caution in hot weather and with other atropine-like drugs
- Possibility of anhidrosis and hyperthermia
- Risk of Neuroleptic Malignant Syndrome
Overdose Effects
- Central symptoms of atropine intoxication
- Peripheral signs of parasympathetic blockade
- Neuropsychiatric signs
- Stupor, coma, paralysis, cardiac and respiratory arrest, and death in severe cases
- Treatment involves symptomatic and supportive therapy, gastric lavage, diazepam administration, respiratory support, fluid replacement, and acid-balance maintenance
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Store at temperature not exceeding 30°C in a dry place
- Protect from light