Probis Plus 2.5 mg+6.25 mg (Tablet)

Indications

• Treatment of Hypertension

Pharmacology

• Bisoprolol Fumarate and Hydrochlorothiazide used individually and in combination for hypertension treatment
• Antihypertensive effects of agents are additive
• Incidence of hypokalemia with Bisoprolol Fumarate and Hydrochlorothiazide 6.25 mg combination is significantly lower than with Hydrochlorothiazide 25 mg
• Bisoprolol Fumarate is a β1-selective (cardioselective) adrenoceptor blocking agent
• Hydrochlorothiazide is a benzothiadiazine diuretic affecting renal tubular mechanisms of electrolyte reabsorption and increasing excretion of sodium and chloride

Dosage & Administration

• Effective doses of Bisoprolol 2.5 to 40 mg and Hydrochlorothiazide 12.5 to 50 mg
• Initial therapy with one 2.5/6.25 mg tablet once daily
• Subsequent titration with maximum recommended dose 20/12.5 mg once daily
• Therapy substitution and guided by clinical effect

Interaction

• Potentiation of action of other antihypertensive agents
• Not to be combined with other beta-blocking agents
• Cautious use with myocardial depressants or AV conduction inhibitors
• Increased risk of bradycardia with concomitant use of digitalis glycosides and beta-blockers

Contraindications

• Cardiogenic shock
• Overt cardiac failure
• Second or third degree AV block
• Marked sinus bradycardia
• Anuria
• Hypersensitivity to either component or other sulfonamide-derived drugs

Side Effects

• Mild and transient side effects
• Side effects may include fatigue, dizziness, headache, bradycardia, arrhythmia, peripheral ischemia, chest pain, palpitations, cold extremities, orthostatic hypotension, gastrointestinal disturbances, rhinitis, pharyngitis

Pregnancy & Lactation

• Pregnancy Category C
• Use during pregnancy only if potential benefit justifies risk to fetus
• Thiazides excreted in human breast milk

Precautions & Warnings

• Possibility of hyperuricemia or acute gout with thiazide diuretics
• Warning signs or symptoms of fluid and electrolyte imbalance
• Hypokalemia risk and gradual withdrawal of therapy

Overdose Effects

• Most frequently observed signs expected with overdose of a beta-blocker are bradycardia and hypotension
• Lethargy, delirium, coma, convulsions, and respiratory arrest reported with severe overdoses
• Acute loss of fluid and electrolytes in thiazide diuretic overdose

Therapeutic Class

• Combined antihypertensive preparations

Storage Conditions

• Keep below 30°C temperature
• Away from light and moisture
• Keep out of the reach of children

Related Brands

• Probis Plus 5 mg+6.25 mg (Tablet) - aci-limited
• Tenobis Plus 2.5 mg+6.25 mg (Tablet) - drug-international-ltd
• Tenobis Plus 5 mg+6.25 mg (Tablet) - drug-international-ltd
• Bisten Plus 2.5 mg+6.25 mg (Tablet) - edruc-limited
• Bisten Plus 5 mg+6.25 mg (Tablet) - edruc-limited