Clacido 875 mg+125 mg (Tablet)

Indications

• Short-term treatment of bacterial infections
• Upper respiratory tract infections
• Lower respiratory tract infections
• Genito-urinary tract infections
• Skin and soft tissue infections
• Bone and joint infections
• Septic abortion
• Puerperal sepsis
• Intra-abdominal sepsis

Composition

• 375 mg tablet
• 625 mg tablet
• 1 gm tablet
• Powder for Suspension
• Powder for Suspension (Forte)
• 1.2 gm Injection
• 0.6 gm injection
• Amoxicillin 250 mg as Amoxicillin Trihydrate
• Clavulanic Acid 125 mg as Diluted Potassium Clavulanate
• Amoxicillin 500 mg as Amoxicillin Trihydrate
• Amoxicillin 875 mg as Amoxicillin Trihydrate
• Clavulanic Acid 125 mg Diluted Potassium Clavulanate
• Amoxicillin 125 mg as Amoxicillin Trihydrate
• Clavulanic Acid 31.25 mg as Diluted Potassium Clavulanate
• Amoxicillin 400 mg as Amoxicillin Trihydrate
• Clavulanic Acid 57.5 mg as Diluted Potassium Clavulanate
• Amoxicillin Sodium BP
• Clavulanate Potassium USP

Pharmacology

• Antibacterial combination of Amoxicillin and Clavulanic Acid
• Broad spectrum of bactericidal activity
• Spectrum of activity against Gram-positive & Gram-negative microorganisms
• Inactivation of beta-lactamase enzymes
• Optimized absorption at the start of a meal
• Low levels of serum binding
• Peak serum levels occur about one hour after oral administration

Dosage

• Recommended adult doses
• Usual dosage for severe infections
• Recommended dosage for suspension based on age
• Usual recommended daily dosage for forte suspension
• Recommended doses for mild to moderate infections in children
• Recommended doses for serious infections in children
• Dosage for IV injection in adults and children

Administration

• Oral dosage form
• IV injection
• Administration without regard to meals
• Enhanced absorption when administered at the start of a meal
• Guidelines for intravenous administration
• Disposal of unused reconstituted vial

Interaction

• Prolongation of bleeding time
• Reduction in efficacy of oral contraceptives
• Concomitant use with allopurinol
• Potential for allergic skin reactions

Contraindications

• History of Penicillin hypersensitivity
• Possible cross-sensitivity with other beta-lactam antibiotics
• Previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice

Side Effects

• Uncommon and mild
• Diarrhoea
• Pseudomembranous colitis
• Indigestion
• Nausea
• Vomiting
• Candidiasis
• Hepatitis
• Urticarial and erythematous rashes
• Erythema multiforme
• Stevens-Johnson Syndrome
• Exfoliative dermatitis
• Angioedema
• Anaphylaxis

Pregnancy & Lactation

• No teratogenic effect in animal studies
• Limited use in human pregnancy
• Detection of Amoxicillin in breast milk

Precautions & Warnings

• Use with care in patients on anticoagulation therapy
• Dose adjustment in patients with severe hepatic dysfunction
• Adjustment of dosage in patients with renal impairment

Use in Special Populations

• Dose adjustment in patients with renal impairment
• Dose adjustment in hepatic impairment

Overdose Effects

• Unlikely occurrence
• Manifestation in gastrointestinal symptoms
• Possibility of haemodialysis for removal from circulation

Therapeutic Class

• Broad spectrum penicillins

Reconstitution

• Reconstitution of 1.2 gm IV injection
• Conditions for reconstitution
• Prohibited reconstitution or mixing with certain solutions
• Injection guidelines

Storage Conditions

• Storage below 25°C
• Protection from light and moisture
• Refrigeration of reconstituted suspension
• Usage period for reconstituted vial

Related Brands

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• Clacido (500 mg+100 mg)/10 ml (IV Injection) - healthcare-pharmaceuticals-ltd
• Demoxiclave 875 mg+125 mg (Tablet) - drug-international-ltd
• Onclav 500 mg+125 mg (Tablet) - one-pharma-ltd
• Onclav (125 mg+31.25 mg)/5 ml (Powder for Suspension) - one-pharma-ltd