Danib 100 mg (Tablet)

Unit Price: ৳ 435.00 (3 x 10: ৳ 13,050.00)
Strip Price: ৳ 4,350.00

Medicine Details

Category Details
Generic Dasatinib
Company Healthcare pharmaceuticals ltd

Indications

  • Treatment of adult patients with newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML)
  • Treatment of chronic, accelerated, or myeloid or lymphoid blast phase Ph+ CML with resistance or intolerance to prior therapy including Imatinib
  • Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) with resistance or intolerance to prior therapy
  • Treatment of pediatric patients 1 year of age and older with Ph+ CML in chronic phase
  • Treatment of newly diagnosed Ph+ ALL in combination with chemotherapy

Pharmacology

  • Inhibition of BCR-ABL, SRC family, c-KIT, EPHA2, and PDGFRβ kinases at nanomolar concentrations
  • Predicted binding to multiple conformations of the ABL kinase
  • Active in leukemic cell lines representing variants of imatinib mesylate-sensitive and resistant disease
  • Metabolism primarily by CYP3A4, FMO-3, and UGT enzymes

Dosage & Administration

  • Recommended starting dosage for chronic phase CML in adults: 100 mg orally once daily
  • Recommended starting dosage for accelerated phase CML, myeloid or lymphoid blast phase CML, or Ph+ ALL in adults: 140 mg orally once daily
  • Dosage for pediatric patients based on body weight
  • Tablets should not be crushed, cut, or chewed; they should be swallowed whole

Interaction

  • Contraindicated with strong CYP3A4 inhibitors
  • Potential for decreased concentrations with strong CYP3A4 inducers
  • Potential for decreased concentrations with gastric acid reducing agents

Contraindications

  • Known hypersensitivity to Dasatinib or any component of the formulation

Side Effects

  • Myelosuppression
  • Bleeding-related events
  • Fluid retention
  • Cardiovascular events
  • Pulmonary arterial hypertension
  • QT prolongation
  • Severe dermatologic reactions
  • Tumor lysis syndrome
  • Effects on growth and development in pediatric patients

Pregnancy & Lactation

  • Potential fetal harm
  • Recommendation to avoid pregnancy and use effective contraceptive methods during treatment
  • Not recommended during breastfeeding

Precautions & Warnings

  • Severe myelosuppression
  • Bleeding-related events
  • Fluid retention
  • Cardiovascular events
  • Pulmonary arterial hypertension
  • QT prolongation
  • Severe dermatologic reactions
  • Tumor lysis syndrome

Overdose Effects

  • Limited clinical study experience with overdose
  • Severe myelosuppression and bleeding observed in reported cases

Therapeutic Class

  • Targeted Cancer Therapy

Storage Conditions

  • Store below 30°C in a dry place
  • Protect from light
  • Keep out of the reach of children

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