Probis Plus 5 mg+6.25 mg (Tablet)

Indications

• Treatment of Hypertension

Pharmacology

• Additive antihypertensive effects of Bisoprolol Fumarate and Hydrochlorothiazide
• Bisoprolol Fumarate is a β1-selective adrenoceptor blocking agent
• Hydrochlorothiazide is a benzothiadiazine diuretic

Dosage & Administration

• Effective once-daily doses for Bisoprolol (2.5 to 40 mg) and Hydrochlorothiazide (12.5 to 50 mg)
• Initial therapy with one 2.5/6.25 mg tablet once daily
• Gradual titration at 14-day intervals
• Substitution for titrated individual components
• Therapy guided by clinical effect

Interaction

• Potentiation of action of other antihypertensive agents
• Not to be combined with other beta-blocking agents
• Close monitoring with catecholamine-depleting drugs
• Caution with myocardial depressants or inhibitors of AV conduction
• Increased risk of bradycardia with concomitant use of digitalis glycosides and beta-blockers

Contraindications

• Cardiogenic shock
• Overt cardiac failure
• Second or third degree AV block
• Marked sinus bradycardia
• Anuria
• Hypersensitivity to either component or to other sulfonamide-derived drugs

Side Effects

• Fatigue
• Dizziness
• Headache
• Bradycardia
• Arrhythmia
• Peripheral ischemia
• Chest pain
• Palpitations
• Rhythm disturbances
• Cold extremities
• Claudication
• Orthostatic hypotension
• Diarrhoea
• Constipation
• Nausea
• Dyspepsia
• Rhinitis
• Pharyngitis

Pregnancy & Lactation

• Pregnancy Category C
• Use in pregnancy only if potential benefit justifies risk to fetus
• Thiazides excreted in human breast milk
• Decision should consider importance of the drug to the mother

Precautions & Warnings

• Potential precipitated hyperuricemia or acute gout
• Warning signs or symptoms of fluid and electrolyte imbalance
• Hypokalemia risk
• Gradual withdrawal over a period of about 2 weeks
• Careful observation of patients

Overdose Effects

• Expected signs of beta-blocker overdose: bradycardia, hypotension, lethargy
• Severe overdoses: delirium, coma, convulsions, respiratory arrest, congestive heart failure, bronchospasm, hypoglycemia
• Thiazide diuretics overdose: acute loss of fluid and electrolytes

Therapeutic Class

• Combined antihypertensive preparations

Storage Conditions

• Keep below 30°C temperature
• Away from light & moisture
• Keep out of the reach of children

Related Brands

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• Bislol Plus 5 mg+6.25 mg (Tablet) - opsonin-pharma-ltd
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