Indapril 2 mg+0.625 mg (Tablet)

Indications

• Treatment of essential hypertension

Pharmacology

• Perindopril is a nonsulphydryl ACE inhibitor
• Perindopril is rapidly hydrolysed to perindoprilat, its principal active metabolite
• Inhibition of ACE activity leads to decreased levels of angiotensin II
• Indapamide inhibits the reabsorption of sodium
• Increases the urinary excretion of sodium and chlorides
• Has an antihypertensive action

Dosage & Administration

• 1-2 tablets per day
• Preferably taken in the morning before a meal
• Treatment should start with an adequate dose in case of renal insufficiency

Interaction

• Concomitant use of antihypertensive & antipsychotic drug may potentiate hypotensive effects
• NSAIDs may reduce the antihypertensive effect
• ARB and Potassium Sparing diuretics may cause hyperkalemia

Contraindications

• Hypersensitivity to perindopril/ indapamide
• Hypersensitivity to any other angiotensin-converting enzyme (ACE) inhibitor

Side Effects

• Nausea
• Vomiting
• Dyspepsia
• Diarrhea
• Constipation
• Headache
• Dizziness
• Sleep disturbance
• Asthenia
• Dry mouth
• Hypotension
• Persistent dry cough
• Angioedema
• Rash

Pregnancy & Lactation

• Not recommended in pregnancy
• Mothers taking Indapa-plus should not breastfeed

Precautions & Warnings

• Use cautiously in renal impairment
• Renal artery stenosis
• Heart failure
• Gout
• Diabetes
• Liver cirrhosis
• In elderly patients
• Atherosclerosis
• Idiopathic or hereditary angioedema

Overdose Effects

• Hypotension
• Nausea
• Vomiting
• Cramps
• Dizziness
• Sleepiness
• Mental confusion
• Oliguria
• Anuria
• Salt and water disturbances
• Gastric lavage or administration of activated charcoal may be used
• Monitor and maintain fluid and electrolyte balance

Therapeutic Class

• Combined antihypertensive preparations

Storage Conditions

• Store below 30°C

Related Brands

• Coversyl Plus 4 mg+1.25 mg (Tablet) - eskayef-pharmaceuticals-ltd