Clix 500 mg (Tablet)
Unit Price: ৳ 40.00 (1 x 6: ৳ 240.00)
Strip Price: ৳ 240.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Acute bacterial exacerbation of chronic bronchitis in adults
- Acute maxillary sinusitis
- Community-acquired pneumonia
- Pharyngitis or tonsillitis
- Uncomplicated skin and skin structure infections
- Acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
- Inhibition of microsomal protein synthesis
- Binding to the donor site on the 50S subunit of the bacterial ribosome
- Prevention of translocation to the donor site
- Activity against most Gram-positive bacteria and Chlamydia
- Activity against some Gram-negative bacteria and Mycoplasmas
- Twice the activity of Erythromycin against H. influenzae
Dosage & Administration
- Dosage for adults
- Combination dosing regimens for H. pylori infection
- Dosage for children
- Dosage in renal and hepatic impairment
Interaction
- Contraindicated co-administration with HMG-CoA reductase inhibitors
- Contraindicated co-administration with gastroprokinetic agents
- Contraindicated co-administration with ergot alkaloids
- Contraindicated co-administration with antipsychotics
- Contraindicated co-administration with anti-gout agents
- Not recommended co-administration with antiarrhythmics drugs
Contraindications
- Known hypersensitivity to clarithromycin
- Cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Stomatitis
- Glossitis
- Headache
- Allergic reactions
- Taste perversion
- Transient central nervous system side effects
- Anxiety
- Dizziness
- Insomnia
- Hallucination
Pregnancy & Lactation
- Suitable for use in neonates and children
- Avoid breastfeeding during treatment
- Not recommended for pregnant patients
Precautions & Warnings
- Discontinue if severe acute hypersensitivity reactions occur
- Avoid in patients with known QT prolongation
- Discontinue if signs and symptoms of hepatitis occur
- Increased risk of all-cause mortality after treatment
- Evaluate for Clostridium difficile associated diarrhea if diarrhea occurs
Use in Special Populations
- Safety and effectiveness in pediatric patients 6 months and older
- Safety and effectiveness in prevention of disseminated Mycobacterium avium complex (MAC) disease in pediatric patients 20 months and older with advanced HIV infection
Overdose Effects
- Ingestion of large amounts can produce gastro-intestinal symptoms
- Prompt elimination of unabsorbed drug and supportive measures for adverse reactions
Therapeutic Class
- Macrolides
Storage Conditions
- Store in a cool and dry place
- Protected from light & moisture
- Reconstituted suspension must be used within specified timeframes
- Keep out of reach of children
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