Enigma 100 mg (Tablet)
Unit Price: ৳ 56.00 (1 x 4: ৳ 224.00)
Strip Price: ৳ 224.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sildenafil citrate |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of erectile dysfunction in men
- Treatment of pulmonary arterial hypertension
Description
- Selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5)
- Results in smooth muscle relaxation and inflow of blood into penile tissues
Mode of Action
- Increases levels of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum
- Produces smooth muscle relaxation in the corpus cavernosum
Pharmacology
- Rapidly absorbed after oral administration
- Eliminated predominantly by hepatic metabolism
Dosage & Administration
- Recommended dose for erectile dysfunction is 50mg
- Maximum recommended dosing frequency is once per day
Interactions
- Metabolism is mediated by cytochrome P450 (CYP) isoforms 3A4 and 2C9
- Inhibitors of these isoenzymes may reduce clearance
Contraindications
- Hypersensitivity to any component of the medication
- Contraindicated in patients using organic nitrates
Side Effects
- Face edema
- Angina pectoris
- Vomiting
- Anemia and leukopenia
- Thirst and edema
- Arthritis and myalgia
- Seizure, anxiety, and transient global amnesia
- Prolonged erection, priapism, and hematuria
Pregnancy & Lactation
- Pregnancy category B
- Not indicated for use by women
Precautions & Warnings
- Caution advised when co-administered with alpha-blockers
- Consideration required for patients with bleeding disorders and active peptic ulceration
Overdose Effects
- Adverse events similar to lower doses but with increased incidence rates and severities
- Standard supportive measures should be adopted in cases of overdose
Therapeutic Class
- Drugs for Erectile Dysfunction
Storage Conditions
- Keep in a dry place, away from light and heat
- Keep out of the reach of children