Etacept 50 mg/ml (SC Injection)

Title & Categories

• Etacept Injection
• Rheumatoid Arthritis Medication
• Immunosuppressant
• Biological Drug

Functions

• Reduces signs and symptoms of Rheumatoid Arthritis (RA)
• Induces major clinical response in RA
• Inhibits the progression of structural damage in RA
• Improves physical function in RA
• Treats polyarticular-course Juvenile Idiopathic Arthritis (JIA)
• Reduces signs and symptoms of Psoriatic Arthritis (PsA)
• Reduces signs and symptoms of Ankylosing Spondylitis (AS)
• Treats chronic moderate to severe Plaque Psoriasis (PsO)

Ingredients

• Etanercept
• Tumor necrosis factor (TNF) blocker
• Human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR)
• Fc portion of human IgG1

Size

Prefilled syringe

Dosage

• 50 mg Etanercept once weekly
• 25 mg Etanercept twice weekly
• 0.4mg/kg (up to maximum of 25 mg per dose) twice weekly for JIA
• 0.8mg/kg (up to maximum of 50 mg per dose) once weekly for pediatric plaque Psoriasis

Age Range

• Adults
• Pediatric patients (from age 2 years for JIA, from age 6 years for Plaque Psoriasis)

Color Options

N/A

Administration

• Subcutaneous injections in the thigh, abdomen, or upper arm
• Injection site rotation
• Single-use prefilled syringe
• Allow to reach room temperature before use
• Needle guard activation for disposal

Contraindications

• Hypersensitivity to etanercept or any component
• Active infections

Side Effects

• Infections
• Injection site reactions
• Allergic reactions
• Fever
• Autoantibody formation
• Serious infections
• Low blood platelet count
• Skin cancer
• Angioedema
• Hives
• Eye inflammation
• Psoriasis
• Rash
• Lung inflammation
• Blood vessel inflammation

Pregnancy & Lactation

• Use during pregnancy only if clearly needed
• Not established for use during lactation
• Excreted in the milk and detected in the serum of lactating rats

Precautions & Warnings

• Allergic reactions
• Infections/surgery
• Infections/diabetes
• Tuberculosis
• Hepatitis-B
• Hepatitis-C
• Blood disorders
• Nervous system and eye disorders
• Congestive heart failure
• Cancer risk
• Chickenpox
• Latex allergies
• Alcohol abuse
• Wegener's granulomatosis
• Anti-diabetic medicine

Overdose Effects

Maximum tolerated dose not established in humans, no known antidote

Therapeutic Class

Immunosuppressant

Storage Conditions

• Refrigeration at 2-8°C
• Do not freeze
• Protect from light
• Keep out of reach of children

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• Enbrel 50 mg/ml (SC Injection) - pfizer