Linlid 400 mg (Tablet)

Unit Price: ৳ 60.00 (2 x 10: ৳ 1,200.00)
Strip Price: ৳ 600.00

Medicine Details

Category Details
Generic Linezolid
Company Team pharmaceuticals ltd
Also available as
Linlid 600 mg tablet Linlid 100 mg suspension

Title

  • Linezolid Tablets
  • Linezolid IV Infusion

Category

  • Antibacterial Agent
  • Oxazolidinones
  • Macrolides
  • Medication

Indications

  • Nosocomial pneumonia
  • Community-acquired pneumonia
  • Complicated skin and skin structure infection
  • Diabetic foot infections
  • Uncomplicated skin and skin structure infections
  • Vancomycin-resistant Enterococcus faecium infections

Pharmacology

  • In vitro activity against Gram positive aerobic bacteria
  • Activity against some Gram positive anaerobic bacteria
  • Activity against certain Gram negative bacteria
  • Selective inhibition of bacterial protein synthesis
  • Binding to the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome
  • Prevention of the formation of a functional 70S initiation complex
  • Bacteriostatic against enterococci and staphylococci
  • Bactericidal for the majority of streptococci strains

Dosage & Administration

  • Oral administration with or without food
  • IV infusion over a period of 30 to 120 minutes
  • Recommended daily dosage for different infections
  • No dose adjustment necessary when switching from IV to oral administration
  • Inspection of IV infusion visually prior to administration
  • No dose adjustment recommended for patients with mild-to-moderate hepatic impairment

Drug Interaction

  • Reversible, nonselective inhibitor of monoamine oxidase
  • Potential for interaction with adrenergic and serotonergic agents
  • Enhancement of pressor response to certain agents
  • Avoidance of large quantities of foods or beverages with high tyramine content

Contraindications

  • Known hypersensitivity to Linezolid or any product components
  • Concomitant use with monoamine oxidase inhibitors
  • Uncontrolled hypertension
  • Pheochromocytoma
  • Thyrotoxicosis
  • Carcinoid syndrome
  • Use of directly and indirectly acting sympathomimetic agents
  • Use of vasopressive agents
  • Use of dopaminergic agents
  • Use of serotonin re-uptake inhibitors
  • Use of tricyclic antidepressants

Side Effects

  • Most adverse events were mild to moderate
  • Common adverse events include diarrhea, headache, and nausea
  • Other adverse events include hypertension, dyspepsia, abdominal pain, pruritus, and tongue discoloration

Pregnancy & Lactation

  • Use during pregnancy if potential benefit justifies potential risk to the fetus
  • Presence in breast milk
  • Consideration of developmental and health benefits of breastfeeding

Precautions & Warnings

  • Monitoring of complete blood counts
  • Ophthalmic evaluation for symptoms of visual impairment
  • Careful medical history for Clostridium difficile-associated Diarrhea
  • Monitoring for potential increases in blood pressure
  • Immediate medical evaluation for specific symptoms
  • Dose adjustment if hypoglycemia occurs

Overdose Effects

  • No reported cases of overdose
  • Symptomatic and supportive care advised
  • Approximately 30% of a Linlid dose removed during 3 hours of haemodialysis
  • No data available for removal by peritoneal dialysis or haemoperfusion

Therapeutic Class

Macrolides

Reconstitution

  • Shaking of the bottle to loosen powder
  • Addition of boiled and cooled water to dry mixture
  • Shaking well before each use
  • Storage in a cool and dry place
  • Use within 21 days after constitution

Storage Conditions

  • Room temperature storage (15°C-30°C)
  • Protection from light and moisture
  • Keep away from children

Related Brands