Linlid 600 mg (Tablet)

Unit Price: ৳ 85.00 (1 x 10: ৳ 850.00)
Strip Price: ৳ 850.00

Medicine Details

Category Details
Generic Linezolid
Company Team pharmaceuticals ltd
Also available as
Linlid 400 mg tablet Linlid 100 mg suspension

Title

Linlid

Categories

  • Antibacterial Agent
  • Medication

Description

Linlid is an antibacterial agent used for the treatment of nosocomial pneumonia, community-acquired pneumonia, skin and skin structure infections, and vancomycin-resistant Enterococcus faecium infections. It belongs to the therapeutic class of Macrolides and has in vitro activity against Gram-positive and Gram-negative bacteria.

Indications

  • Nosocomial pneumonia
  • Community-acquired pneumonia
  • Complicated skin and skin structure infection
  • Uncomplicated skin and skin structure infections
  • Vancomycin-resistant Enterococcus faecium infections

Mode of Action

Linezolid selectively inhibits bacterial protein synthesis by binding to the 23S ribosomal RNA of the 50S subunit, preventing the formation of a functional 70S initiation complex which is essential for the bacterial translation process.

Dosage & Administration

  • Infection:
    • Nosocomial pneumonia
    • Community-acquired pneumonia
    • Complicated skin and skin structure infections
    • Uncomplicated skin and skin structure infections
  • Dosage, route and frequency of administration:
    • Pediatric patients* (birth through 11 years of age): 10 mg/kg orally or intravenously every 8 hours
    • Adults and adolescent (12 years and older): 600 mg orally or intravenously every 12 hours
    • Recommended duration of treatment (consecutive days): 10 to 14, 14 to 28
  • Intravenous administration: Linezolid IV infusion should be administered over a period of 30 to 120 minutes. No dose adjustment is necessary when switching from intravenous to oral administration.
  • Hepatic impairment: No dose adjustment is recommended for patients with mild-to-moderate hepatic impairment. The pharmacokinetics of Linezolid in patients with severe hepatic impairment have not been evaluated.
  • Use in children and adolescents: The dose of linezolid for children and adolescents have been described in dose and administration section. The use of linezolid for the empiric treatment of pediatric patients with central nervous system infections is not recommended

Interaction

  • Drug interaction with medication: Linezolid has the potential for interaction with adrenergic and serotonergic agents. Careful observation is required when administering Linlid to patients with specific preexisting conditions or taking certain medications.
  • Drug interaction with food and others: Patients are advised to avoid large quantities of foods or beverages with high tyramine content while taking Linlid.

Contraindications

Linlid is contraindicated for use in patients who have known hypersensitivity to Linezolid or any of the other product components. It should not be used in patients taking any medicinal product which inhibits monoamine oxidases A or B or within two weeks of taking any such medicinal product.

Side Effects

  • Diarrhea
  • Headache
  • Nausea
  • Hypertension
  • Dyspepsia
  • Abdominal pain
  • Pruritus
  • Tongue discoloration

Pregnancy & Lactation

  • Pregnancy: Linezolid should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
  • Lactation: The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for linezolid and any potential adverse effects on the breastfed child.

Precautions & Warnings

Complete blood counts should be monitored weekly in patients who receive Linlid, particularly in those who receive Linlid for longer than two weeks, those with pre-existing myelosuppression, those receiving concomitant drugs that produce bone marrow suppression or those with a chronic infection who have received previous or concomitant antibiotic therapy. If patients experience symptoms of visual impairment, prompt ophthalmic evaluation is recommended.

Overdose Effects

No cases of overdose have been reported. Symptomatic and supportive care is advised together with maintenance of glomerular filtration.

Therapeutic Class

Macrolides

Reconstitution

  • Oral Suspension: Shake the bottle to loosen powder. Add 75 ml of boiled and cooled water to the dry mixture in the bottle. Shake well after each addition until all the powder is in suspension. The reconstituted suspension should be stored in a cool and dry place and used within 21 days after constitution.
  • Intravenous Administration: Linlid IV Injection should be administered by intravenous infusion over a period of 30 to 120 minutes.

Storage Conditions

Linlid formulations should be stored at room temperature (15°C-30°C), away from light and moisture.

Related Brands