Maxnor 4 mg/4 ml (IV Infusion)
4 ml ampoule: ৳ 480.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Norepinephrine bitartrate |
| Company | Healthcare pharmaceuticals ltd |
Indications
- blood pressure control
- acute hypotensive states
- pheochromocytomectomy
- sympathectomy
- myocardial infarction
- septicemia
- blood transfusion
- drug reactions
- cardiac arrest
- profound hypotension
Pharmacology
- direct-acting sympathomimetic
- stimulates alpha-adrenergic receptors
- vasoconstriction
- raises systolic and diastolic BP
- reflex slowing of heart rate
Dosage & Administration
- infusion into a large vein
- blood volume depletion correction
- diluent: 5 percent dextrose injection or 5 percent dextrose and sodium chloride injections
- average dosage: 4 mcg/ml diluted in 5% dextrose solution
- high dosage titrated according to patient response
- duration of therapy
- adjunctive treatment in cardiac arrest
Interaction
- contraindicated with cyclopropane and halothane anesthesia
- risk of cardiac arrhythmias with profound hypoxia or hypercarbia
- caution with monoamine oxidase inhibitors or tricyclic antidepressants
Contraindications
- hypotensive from blood volume deficits
- mesenteric or peripheral vascular thrombosis
- contraindicated with cyclopropane and halothane anesthesia
- cardiac arrhythmia risk with hypoxia or hypercarbia
Side Effects
- ischemic injury
- bradycardia
- arrhythmias
- anxiety
- headache
- respiratory difficulty
- extravasation necrosis at injection site
- plasma volume depletion
- gangrene of extremities
- severe hypertension in hypersensitive persons
Pregnancy & Lactation
- Pregnancy Category C
- caution in use during pregnancy and lactation
Precautions & Warnings
- avoid hypertension
- site of infusion
- extravasation precautions
- antidote for extravasation ischemia
Use in Special Populations
- safety and effectiveness in pediatric patients not established
- cautious use in geriatric patients
- no studies for carcinogenesis, mutagenesis, impairment of fertility
Overdose Effects
- headache
- severe hypertension
- reflex bradycardia
- decreased cardiac output
- discontinue until patient stabilizes
Therapeutic Class
- alpha and beta-adrenergic agonist
Reconstitution
- intravenous reconstitution with 5% glucose inj
- dilution with or without sodium chloride
- not recommended with sodium chloride inj alone
Storage Conditions
- temperature not exceeding 30°C
- dry place
- protect from light