Thoraz 250 mg (Tablet)

Indications

• Lower respiratory tract infections
• Upper respiratory tract infections
• Otitis media
• Skin and soft tissue infections
• Non-gonococcal urethritis
• Cervicitis due to Chlamydia trachomatis

Pharmacology

• Time to peak concentration: 2.1 to 3.2 hours
• Active transportation to site of infection
• High concentration in phagocytes
• Binding to 50S ribosomal subunit
• Interference with microbial protein synthesis

Dosage

• Adult dosage: 500 mg once daily orally for 3 days
• Children dosage: 10 mg/kg body weight once daily for 3 days
• IV infusion dosage for adult patients with pneumonia

Administration

• Oral administration
• Reconstitution procedure for suspension
• Should be taken at least 1 hour before or 2 hours after meal

Interaction

• Interaction with antacids
• Potential interaction with carbamazepine
• Interference with cyclosporin metabolism
• Impairment of digoxin metabolism
• Potential risk of ergotism
• No significant pharmacokinetic interaction with theophylline

Contraindications

• Hypersensitivity to Azithromycin or macrolide antibiotics
• Co-administration with ergot derivatives
• Patients with hepatic diseases

Side Effects

• Gastrointestinal side-effects
• Allergic reactions such as rash or photosensitivity
• Reversible elevations in liver transaminases
• Rare cases of cholestatic jaundice
• Transient mild reductions in neutrophil counts
• Reversible hearing impairment

Pregnancy & Lactation

• Pregnancy Category B
• No adequate and well controlled studies in pregnant women
• Caution required during nursing

Precautions & Warnings

• Rare serious allergic reactions reported
• Recurrent symptoms of allergic reactions
• Caution in patients with renal impairment
• Avoid use in patients with hepatic impairment

Overdose Effects

• Typical symptoms of macrolide antibiotics overdose
• Indication of gastric lavage and supportive measures

Storage Conditions

• Keep in a dry place away from light and heat
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C38H72N2O12
• Chemical Structure Image

Common Questions about Thoraz 250 mg Tablet

• Action of Thoraz 250 mg Tablet
• Uses of Thoraz 250 mg Tablet
• Side Effects of Thoraz 250 mg Tablet
• Storage and disposal instructions
• Possibility of diarrhea
• Safety of Thoraz 250 mg Tablet
• Classification as an antibiotic
• Course of action if symptoms persist

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