Anaprox 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Naproxen sodium esomeprazole magnesium
Company Al madina pharmaceuticals ltd

Indications

  • Relief of signs and symptoms of osteoarthritis
  • Relief of signs and symptoms of rheumatoid arthritis
  • Relief of signs and symptoms of ankylosing spondylitis
  • Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Pharmacology

  • Immediate release Esomeprazole Magnesium layer
  • Enteric-coated Naproxen core
  • Inhibition of prostaglandin synthesis
  • Suppression of gastric acid secretion
  • Specific inhibition of the H⁺/k⁺ -ATPase in the gastric parietal cell

Dosage

  • Use lowest effective dose
  • Adult dosage: One tablet twice daily of either 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole
  • Adolescent dosage: 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole for weight greater than 50 kg, 375 mg naproxen/20 mg of esomeprazole for weight 38 kg to less than 50 kg

Administration

  • Tablet to be taken at least 30 minutes before meals

Interaction

  • Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
  • Increased risk of bleeding complication with warfarin
  • Interference with absorption of drugs where gastric pH is an important determinant of bioavailability
  • Effect on absorption when administered with high-fat food

Contraindications

  • Known hypersensitivity to any component of the tablet or substituted benzimidazoles
  • History of allergic-type reactions after taking aspirin or other NSAIDs
  • Use during peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Side Effects

  • Decrease in occurrence of gastric ulcers and NSAID associated upper gastrointestinal adverse events
  • Increased risk of arterial thrombotic events at high doses and in long-term treatment
  • Gastrointestinal adverse events such as peptic ulcers, perforation, GI bleeding, oedema, hypertension, cardiac failure
  • Nausea, vomiting, diarrhoea, constipation, dyspepsia, abdominal pain, melaena, haematemesis, gastritis

Pregnancy & Lactation

  • Not recommended during third trimester of pregnancy
  • Excretion in low quantities in human milk
  • Not recommended during breastfeeding
  • Impairment of female fertility

Precautions & Warnings

  • Avoid combination with NSAIDs and cyclooxygenase-2 selective inhibitors
  • Minimize undesirable effects using lowest effective dose for shortest duration
  • Risk-factors for NSAID related gastro-intestinal complications
  • Special caution for older people
  • Gastrointestinal, cardiovascular, cerebrovascular, and renal effects

Use in Special Populations

  • Increased unbound plasma fraction of naproxen in elderly
  • Not recommended for use in patients with moderate to severe or severe renal impairment
  • Consideration for patients with hepatic insufficiency

Overdose Effects

  • Symptoms related to naproxen overdose
  • Symptoms related to esomeprazole overdose
  • No specific antidotes
  • Management by symptomatic and supportive care

Therapeutic Class

  • Drugs for Osteoarthritis
  • Drugs used for Rheumatoid Arthritis
  • Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

  • Store at temperature below 30°C
  • Protect from light & moisture
  • Keep out of reach of children

Related Brands