Gastrazole 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Al madina pharmaceuticals ltd

Therapeutic Class

  • Proton Pump Inhibitor

Indications

  • Treatment of active duodenal ulcer
  • Treatment of active benign gastric ulcer
  • Symptomatic treatment of erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Gastro-esophageal reflux disease long-term management (GERD maintenance)
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Zollinger-Ellison Syndrome
  • In combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori in patients with peptic ulcer disease

Pharmacology

  • Suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase at the secretory surface of the gastric parietal cell
  • Characterized as a gastric proton-pump inhibitor

Dosage

  • Recommended oral dose for active duodenal ulcer and active benign gastric ulcer is 20 mg once daily in the morning
  • Recommended oral dose for erosive or ulcerative gastro-esophageal reflux disease (GERD) is 20 mg once daily for four to eight weeks
  • For long-term management, a maintenance dose of rabeprazole sodium 20 mg or 10 mg once daily can be used depending upon patient response
  • Dosage for treatment of moderate to very severe gastro-esophageal reflux disease, zollinger-ellison syndrome, and eradication of H. pylori

Administration

  • Tablets should be taken in the morning, before eating

Interaction

  • May interact with compounds whose absorption is pH dependent
  • Co-administration with ketoconazole or itraconazole may result in a significant decrease in antifungal plasma levels
  • No interaction with liquid antacids was observed

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Contra-indicated in pregnancy and during breastfeeding

Side Effects

  • May cause headache, diarrhea, abdominal pain, vomiting, etc.

Pregnancy & Lactation

  • US FDA pregnancy category 'C'
  • No adequate and well-controlled studies in pregnant women
  • Likely to be excreted in human milk

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric or esophageal malignancy
  • Patients on long-term treatment should be kept under regular surveillance
  • Possible increase in the risk of hip, wrist and spine fracture, particularly in the elderly
  • Risk of cross-hypersensitivity reactions with other proton pump inhibitor or substituted benzimidazoles
  • Caution in patients with hepatic impairment
  • Hypomagnesaemia, influence on vitamin B12 absorption, subacute cutaneous lupus erythematosus (SCLE) and interference with laboratory tests

Use in Special Populations

  • No dosage adjustment necessary for patients with renal or hepatic impairment
  • Not recommended for use in children due to a lack of data on safety and efficacy

Overdose Effects

  • Effects are generally minimal, representative of the known adverse event profile and reversible without further medical intervention
  • No specific antidote is known

Storage Conditions

  • Keep below 30°C temperature, away from light & moisture
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C18H21N3O3S

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