Alphapress XR 5 mg (Tablet (Extended Release))
Unit Price: ৳ 17.00 (3 x 10: ৳ 510.00)
Strip Price: ৳ 170.00
Medicine Details
Category | Details |
---|---|
Generic | Prazosin hydrochloride |
Company | Renata limited |
Also available as |
Indications
- Treatment of essential (primary) hypertension
- Treatment of secondary hypertension
- Treatment of left ventricular failure
- Treatment of Raynaud's phenomenon and disease
- Adjunct in symptomatic treatment of urinary obstruction caused by benign prostatic hyperplasia
Pharmacology
- Decrease in total peripheral vascular resistance through selective inhibition of postsynaptic alpha-1-adrenoreceptors in vascular smooth muscle
- Therapeutic efficacy in congestive heart failure
- Reduction in severity of signs, symptoms, frequency, and duration of attacks in patients with Raynaud's disease
- Improvement of urinary pressure profile in men with benign prostatic hyperplasia
Dosage & Administration
- Adjustment of dosage according to patient's individual toleration
- Initiation with low starting dose for best toleration
- Maintenance dosage for hypertension
- Titration of dosage for left ventricular failure
- Starting dosage and maintenance dosage for Raynaud's phenomenon and disease
- Recommended starting dose and usual maintenance dose for benign prostatic hyperplasia
- Initiation of therapy with Prazosin XR
- Titration of dosage for hypertensive patients controlled on Prazosin Tablets
- Addition of diuretic or other antihypertensive agent to prazosin
Interaction
- Administration without adverse drug interaction with cardiac-glycosides-digitalis and digoxin
- Administration without adverse drug interaction with hypoglycemic agents-insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide
- Administration without adverse drug interaction with tranquilizers and sedatives-chlordiazepoxide, diazepam, and phenobarbital
- Administration without adverse drug interaction with antiarrhythmic agents-procainamide, propranolol, and quinidine
- Administration without adverse drug interaction with analgesic, antipyretic, and anti-inflammatory agents-propxyphene, aspirin, indomethacin, and phenylbutazone type
Contraindications
- Known sensitivity to quinazolines
Side Effects
- Dizziness
- Headache
- Drowsiness
- Palpitations
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal discomfort and/or pain
- Liver function abnormalities
- Edema
- Orthostatic hypotension
- Dyspnea
- Faintness
- Tachycardia
- Nervousness
- Vertigo
- Hallucinations
- Depression
- Rash
- Pruritus
- Urinary frequency
- Impotence
- Incontinence
- Priapism
- Blurred vision
- Reddened solera
- Epistaxis
- Tinnitus
- Dry mouth
- Nasal congestion
- Diaphoresis
- Fever
- Positive ANA liter
- Arthralgia
- Worsening of pre-existing narcolepsy
Pregnancy & Lactation
- No teratogenic effects seen in animal testing
- Recommended cautious use during pregnancy
- Excretion in small amounts in human milk
- Caution in administration to nursing mothers
Precautions & Warnings
- Avoidance of postural hypotension symptoms during initiation of therapy
- Avoidance of situations where injury could result from dizziness or weakness
- Importance of careful adjustment of diuretic dosage for patients with left ventricular failure
- Close monitoring of blood pressure during administration to patients already taking medications known to lower blood pressure
Use in Special Populations
- Not recommended for children under the age of 12 years
- Not recommended in the treatment of left ventricular failure due to mechanical obstruction
Overdose Effects
- Accidental ingestion and resulting effects
- Support of cardiovascular system in case of hypotension
- Monitoring and support of renal function
- Not dialyzable because it is protein bound
Therapeutic Class
- Alpha adrenoceptor blocking drugs
Storage Conditions
- Keep away from light and moisture
- Store below 30°C
- Keep away from reach out of the children
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