Antogin ER 500 mg (Tablet (Extended Release))

Unit Price: ৳ 16.00 (4 x 5: ৳ 320.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Ranolazine
Company Renata limited

Indications

  • Treatment of chronic angina
  • Decrease angina episodes in patients with coronary artery disease
  • Use with beta-blockers, nitrates, calcium channel blockers, anti-platelet therapy, lipid-lowering therapy, ACE inhibitors, and angiotensin receptor blockers

Pharmacology

  • Anti-ischemic effects
  • Antianginal effects
  • Inhibition of cardiac late sodium current (I_Na)
  • Inhibition of I_Kr
  • Absorption: C_max at 2-5 h
  • Half-life: 6-22 h
  • Distribution: Approximately 62% bound to human plasma proteins
  • Metabolism by CYP3A and CYP2D6
  • Excretion mainly in urine and feces

Dosage & Administration

  • Initiate dosing at 500 mg twice daily
  • Increase to 1000 mg twice daily if needed
  • Swallow tablets whole, do not crush, break or chew
  • Maximum recommended daily dose is 1000 mg twice daily
  • Prescribed dose may be taken at the next scheduled time if missed, without doubling the next dose

Interaction

  • Avoid use with strong CYP 3A inhibitors
  • Limit maximum dose with moderate CYP 3A inhibitors
  • Consider dose adjustment with P-gp inhibitors or CYP2D6-metabolized drugs

Contraindications

  • Pre-existing QT prolongation
  • Hepatic impairment
  • Taking QT prolonging drugs
  • Taking potent and moderately potent CYP3A inhibitors

Side Effects

  • Bradycardia
  • Palpitations
  • Tinnitus
  • Vertigo
  • Abdominal pain
  • Dry mouth
  • Vomiting
  • Peripheral edema
  • Dyspnea
  • Hypotension
  • Orthostatic hypotension

Pregnancy & Lactation

  • Pregnancy Category C
  • No adequate studies on its effect on the developing fetus
  • No well-controlled studies in pregnant women
  • Caution in nursing mothers
  • Potential risk to the fetus

Precautions & Warnings

  • Blocks QTc and prolongs the QTc interval
  • Caution when co-administered with digoxin or P-gp inhibitors
  • No increased risk of proarrhythmia or sudden death in acute coronary syndrome population

Overdose Effects

  • Dose-related increases in dizziness, nausea, and vomiting
  • Diplopia
  • Paresthesia
  • Confusion
  • Syncope
  • General supportive measures needed
  • Continuous ECG monitoring warranted
  • Hemodialysis unlikely to be effective

Therapeutic Class

  • Other Anti-anginal & Anti-ischaemic drugs

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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