Oxyton DS 10 IU/ml (IM/IV Injection)
10 IU ampoule: ৳ 25.69 (2 x 5: ৳ 256.90)
Medicine Details
| Category | Details |
|---|---|
| Generic | Oxytocin |
| Company | Renata limited |
| Also available as |
Indications
- Induction of labor
- Stimulation of uterine contractions
- Post-delivery period for prevention or treatment of secondary hemorrhage
- Adherent placenta prevention or treatment
- Stimulate lactation
- Treatment of incomplete abortion
Description
- Active substance: synthetically prepared Oxyton DS
- Identical to natural occurring hormone from posterior pituitary gland
- Causes contractions of the uterus
- Mimics contractions of normal labor
- Impedes uterine blood flow
- Increases amplitude and duration of uterine contractions
- Leads to dilation and effacement of the cervix
- Stimulates the smooth muscle associated with secretory epithelium of the lactating breast
- Causes ejection of milk from mammary ductular system
- Minimal cardiovascular and antidiuretic properties
Pharmacology
- Promotes contractions by increasing intracellular Ca2+
- Activates myosin's light chain kinase
- Specific receptors in muscle lining of the uterus
- Receptor concentration increases greatly during pregnancy
- Reaches maximum in early labor at term
Dosage & Administration
- Intravenous infusion under adequate control
- Dosage can be doubled every 30-45 minutes
- Intramuscular administration may lead to irregular response
- Dosage should not exceed 0.5-1 IU per injection
- Intramuscular injection of 2-5 IU post-delivery
- Intramuscular injection of 2 IU to stimulate lactation
- Intramuscular injection of 2-5 IU for incomplete abortion treatment
Interaction
- Severe hypertension reported when given following prophylactic vasoconstrictor with caudal-block anesthesia
- Cyclopropane anesthesia may modify cardiovascular effects
- Maternal sinus bradycardia with abnormal atrioventricular rhythms noted when used concomitantly with cyclopropane anesthesia
Contraindications
- Cephalo-pelvic disproportion
- Abnormal position of the child or skull
- Overdistention of the inferior segment of the uterus
- Severe toxaemia
- Hypertonic uterine dysfunction
- Foetal distress without imminent delivery
- Cord presentation and prolapse
- Total placenta previa
- Vasa previa
Side Effects
- Hypersensitivity may result in uterine hypertonicity or rupture
- Possibility of increased blood loss and afbrinigenemia
- Severe water intoxication with convulsions and coma
- Nausea, vomiting, hemorrhage, cardiac arrhythmias, anaphylactic reaction
- Increased incidence of icterus neonatorum
Pregnancy & Lactation
- Pregnancy category C
- Not known whether excreted in human milk
Precautions & Warnings
- Uterine sensitivity may vary widely
- Smallest effective dose must be determined for each patient
- Medical supervision should be provided
- Fetal heart rate and maternal blood pressure should be determined
- Use with care if scars of the uterus and cervix uteri exist
Overdose Effects
- Violent uterine contractions
- Fetal bradycardia and arrhythmias
- Extensive laceration of soft tissues
- Uterine rupture and potential fetal or maternal death
Therapeutic Class
- Drugs acting on the Uterus
Reconstitution
- Oxyton DS maintains potency for at least 24 hours when diluted with specific infusion fluids
- Direct injection into the infusion line is possible with certain infusion fluids
Storage Conditions
- Store between 2 to 8°C in a dark, frost-free place