Tyrokin 100 mg (Tablet)
Unit Price: ৳ 100.00 (1 x 10: ৳ 1,000.00)
Strip Price: ৳ 1,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Imatinib mesylate |
| Company | Renata limited |
| Also available as |
Indications
- Treatment for Philadelphia chromosome positive chronic myeloid leukemia (Ph+CML)
- Treatment for Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL)
- Treatment for myelodysplastic/myeloproliferative diseases
- Treatment for aggressive systemic mastocytosis
- Treatment for hypereosinophilic syndrome and chronic eosinophilic leukemia
- Treatment for dermatofibrosarcoma protuberans
- Adjuvant treatment for GIST after resection
- Adjuvant treatment for unresectable GIST
- Reduction of fluid retention and edema
- Management of hemorrhage and gastrointestinal disorders
Pharmacology
- Inhibition of Bcr-Abl tyrosine kinase
- Inhibition of receptor tyrosine kinases: Kit, PDGFR-alpha, PDGFR-beta, DDR1 and DDR2
- High oral bioavailability
- Metabolism by CYP3A4 enzyme
- Predominant elimination in feces
- Plasma protein binding
Dosage & Administration
- Dosage for adults with Ph+ CML CP, AP, BC, ALL, MDS/MPD, ASM, HES/CEL, DFSP, and GIST
- Dosing with a meal and large glass of water
- Dissolving in water or apple juice for patients with swallowing difficulties
- Administration with a reduced iron exposure
Interaction
- Interaction with agents inducing or inhibiting CYP3A metabolism
- Interaction with drugs metabolized by CYP3A4 and CYP2D6
- Caution with CYP3A4 substrates with narrow therapeutic window
Side Effects
- Fluid retention and edema
- Hematologic toxicity
- Cardiac toxicities
- Hepatotoxicity
- Hemorrhage and gastrointestinal disorders
- Dermatologic toxicities
- Hypothyroidism
- Growth retardation in children and adolescents
Pregnancy & Lactation
- Necessity of effective contraception during treatment
- Limited data on use in pregnant women
- Reproductive toxicity in animal studies
- Distribution into human milk
- Unknown effects on infant from low-dose exposure
Precautions & Warnings
- Regular weighing for edema management
- Monitoring of cytopenias
- Monitoring of cardiac function and risk factors
- Assessment of liver function
- Management of hemorrhage and cardiogenic shock
- Monitoring of growth in children and pre-adolescents
- Caution with driving and machinery operation
Overdose Effects
- Reported symptoms in adult and pediatric populations
- Observation and symptomatic treatment in case of overdose
Therapeutic Class
- Targeted Cancer Therapy
- Tyrosine Kinase Inhibitor
Storage Conditions
- Storage temperature below 30°C
- Storage in a cool, dry place
- Protection from light
- Keep out of the reach of children