Glifo-M 5 mg+500 mg (Tablet)

Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00

Medicine Details

Category Details
Generic Empagliflozin metformin hydrochloride
Company Acme laboratories ltd
Also available as
Glifo m 125 mg tablet Glifo m xr 10 mg tablet Glifo m xr 25 mg tablet Glifo m xr 5 mg tablet

Indications

  • Treatment of adults with type 2 diabetes mellitus
  • Adjunct to diet and exercise
  • In combination with Metformin
  • In combination with Empagliflozin

Pharmacology

  • Empagliflozin is an SGLT2 inhibitor
  • Metformin Hydrochloride is a biguanide type oral antihyperglycemic drug
  • Empagliflozin reduces renal reabsorption of filtered glucose
  • Metformin lowers basal and postprandial plasma glucose

Dosage & Administration

  • Individualized based on effectiveness and tolerability
  • Take twice daily with meals
  • Dose escalation should be gradual
  • Maximum recommended daily doses

Interaction

  • Diuretics increase urine volume and frequency of voids
  • Co-administration with insulin increases risk for hypoglycemia
  • Monitoring glycemic control with urine glucose tests is not recommended
  • Drugs that reduce Metformin clearance may increase accumulation

Contraindications

  • Hypersensitivity to Empagliflozin and Metformin
  • Acute metabolic acidosis
  • Diabetic pre-coma
  • Severe renal failure
  • Acute conditions altering renal function
  • Diseases causing tissue hypoxia
  • Hepatic impairment
  • Acute alcohol intoxication
  • Alcoholism

Side Effects

  • Urinary tract infection
  • Female genital mycotic infections
  • Diarrhea
  • Nausea/vomiting
  • Flatulence
  • Abdominal discomfort
  • Hypoglycemia
  • Vaginal moniliasis
  • Increased urination

Pregnancy & Lactation

  • Potential risk to a fetus
  • Not recommended during breastfeeding

Precautions & Warnings

  • Lactic acidosis
  • Hypotension
  • Ketoacidosis
  • Acute kidney injury & impairment in renal function
  • Urosepsis, Pyelonephritis, Fournier’s gangrene & genital mycotic infections
  • Hypoglycemia
  • Vitamin B12 Deficiency
  • Increased LDL-C
  • Macrovascular Outcomes

Overdose Effects

  • No toxicity with single doses of up to 800 mg Empagliflozin
  • Hypoglycemia not seen with Metformin doses of up to 85 g
  • Lactic acidosis is a medical emergency
  • Treatment should be initiated as appropriate to the patient's clinical status

Therapeutic Class

Oral hypoglycemic preparations

Storage Conditions

Keep below 30°C temperature, protected from light & moisture, Keep out of the reach of children

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