Cykin 125 mg (Capsule)
Unit Price: ৳ 400.00 (7 x 4: ৳ 11,200.00)
Strip Price: ৳ 1,600.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Palbociclib |
| Company | Genvio pharma ltd |
Indications
- HR-positive breast cancer treatment
- Metastatic breast cancer treatment
- Treatment in postmenopausal women
- Fulvestrant treatment
- Combination therapy
- Endocrine-based therapy
Pharmacology
- Cyclin-dependent kinase 4/6 inhibitor
- Cellular proliferation inhibition
- Cell cycle progression blockage
- RB protein phosphorylation reduction
- E2F expression suppression
- Growth arrest induction
- Cell senescence enhancement
- Tumor growth inhibition
Dosage & Administration
- 125mg capsule
- Once daily dosing
- 21 days on, 7 days off cycle
- Oral administration
- Taken with food
- Consistent dosing time
- Adverse reaction dose modification
- LHRH agonist for men
Interaction
- Metabolized by CYP3A and SULT enzyme
- Time-dependent CYP3A inhibitor
- Plasma concentration altering agents
- CYP3A inhibitors and inducers
- Alteration of other drug plasma concentrations
Side Effects
- WBC and platelet decrease
- Neutropenia
- Infections
- Liver enzyme increase
- GI disturbances
- Hair loss
- Weakness
- Skin conditions
- Fever
Pregnancy & Lactation
- Fetal harm risk
- Risk percentages for birth defects and miscarriage
Precautions & Warnings
- Neutropenia monitoring
- Febrile neutropenia risk
- Interstitial lung disease/pneumonitis risk
- Embryo fetal toxicity
- Contraception recommendation
Overdose Effects
- No known antidote
- General supportive measures
Therapeutic Class
- Protein kinase inhibitor
Storage Conditions
- Temperature restriction
- Protection from light and moisture
- Keep out of reach of children