Tranbit 25 mg (Tablet)
Unit Price: ৳ 90.00 (3 x 10: ৳ 2,700.00)
Strip Price: ৳ 900.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tenofovir alafenamide |
| Company | Genvio pharma ltd |
Indications
- Treatment of chronic hepatitis B virus infection
- For adults with compensated liver disease
Pharmacology
- Tenofovir alafenamide as a nucleoside analog reverse transcriptase inhibitor
- Converted to tenofovir through hydrolysis by carboxylesterase 1 (CES1)
- Inhibits HBV replication through incorporation into viral DNA
- Weak inhibitor of mammalian DNA polymerases
Dosage & Administration
- Recommended dosage of 25 mg once daily with food
- No dosage adjustment required in patients with certain renal impairment
- Not recommended in patients with decompensated hepatic impairment
- Safety and effectiveness not established in pediatric patients
- Administered to elderly subjects with no clinically significant differences observed
Interaction
- Substrate of P-glycoprotein (P-gp) and BCRP
- Drugs affecting P-gp activity may lead to changes in absorption
- Coadministration with other drugs may affect absorption and plasma concentration
- Drugs affecting renal function may increase concentrations
Side Effects
- Headache
- Stomach pain
- Tiredness
- Cough
- Nausea
- Back pain
Pregnancy & Lactation
- Prevalence of birth defects in live births following exposure to TAF-containing regimens
- Effect on human milk production and breastfed infant unknown
- Consider developmental and health benefits of breastfeeding
Precautions & Warnings
- Risk of severe acute exacerbations of hepatitis B after discontinuation of treatment
- Risk of development of HIV-1 resistance in patients coinfected with HBV and HIV-1
- Renal impairment including acute renal failure reported
- Lactic acidosis and severe hepatomegaly with steatosis reported
Overdose Effects
- Monitor patient for evidence of toxicity
- General supportive measures for overdose
- Efficiently removed by hemodialysis
Therapeutic Class
- Hepatic viral infections (Hepatitis B)
Storage Conditions
- Store below 30°C
- Keep in original container
- Protect from light
- Keep out of children's reach