Trepmac 90 mg (Tablet)
Unit Price: ৳ 1,400.00 (3 x 10: ৳ 42,000.00)
Strip Price: ৳ 14,000.00
Medicine Details
Category | Details |
---|---|
Generic | Brigatinib |
Company | Genvio pharma ltd |
Indications
- Treatment of ALK-positive metastatic Non-small cell lung cancer (NSCLC)
Pharmacology
- Tyrosine kinase inhibitor
- Inhibits autophosphorylation of ALK
- Inhibits ALK-mediated phosphorylation of signaling proteins
- Metabolized by CYP2C8 and CYP3A4
Absorption
- Median time to peak concentration (Tmax) ranged from 1 to 4 hours
Distribution
- 66% bound to human plasma proteins
- Mean apparent volume of distribution (Vz/F) at steady-state was 153 L
Elimination
- Mean apparent oral clearance (CL/F) at steady-state is 12.7 L/h
- Mean plasma elimination half-life is 25 hours
Metabolism
- Metabolized by CYP2C8 and CYP3A4
- Primary metabolite: AP26123
Excretion
- 65% recovered in feces
- 25% recovered in urine
Dosage & Administration
- 90 mg orally once daily for the first 7 days
- If 90 mg is tolerated, increase to 180 mg orally once daily
- May be taken with or without food
- Tablets should not be crushed or chewed
Interaction
- CYP3A Inhibitors may increase plasma concentrations
- CYP3A Inducers may decrease plasma concentrations
- CYP3A Substrates may have altered plasma concentrations
Contraindications
- Known hypersensitivity to Brigatinib or any other components
Side Effects
- Interstitial Lung Disease (ILD)/Pneumonitis
- Hypertension
- Bradycardia
- Visual Disturbance
- Creatine Phosphokinase (CPK) Elevation
- Pancreatic Enzyme Elevation
- Hyperglycemia
Pregnancy & Lactation
- No clinical data on use in pregnant women
- Adverse reactions in breastfed infants
- Advice on effective non-hormonal contraception
- Potential for reduced fertility in males
Precautions & Warnings
- Severe pulmonary adverse reactions
- Hypertension monitoring and control
- Bradycardia monitoring
- Visual disturbance monitoring
- CPK and pancreatic enzyme elevation monitoring
- Hyperglycemia monitoring
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of reach of children