Trepmac 90 mg (Tablet)

Unit Price: ৳ 1,400.00 (3 x 10: ৳ 42,000.00)
Strip Price: ৳ 14,000.00

Medicine Details

Category Details
Generic Brigatinib
Company Genvio pharma ltd

Indications

  • Treatment of ALK-positive metastatic Non-small cell lung cancer (NSCLC)

Pharmacology

  • Tyrosine kinase inhibitor
  • Inhibits autophosphorylation of ALK
  • Inhibits ALK-mediated phosphorylation of signaling proteins
  • Metabolized by CYP2C8 and CYP3A4

Absorption

  • Median time to peak concentration (Tmax) ranged from 1 to 4 hours

Distribution

  • 66% bound to human plasma proteins
  • Mean apparent volume of distribution (Vz/F) at steady-state was 153 L

Elimination

  • Mean apparent oral clearance (CL/F) at steady-state is 12.7 L/h
  • Mean plasma elimination half-life is 25 hours

Metabolism

  • Metabolized by CYP2C8 and CYP3A4
  • Primary metabolite: AP26123

Excretion

  • 65% recovered in feces
  • 25% recovered in urine

Dosage & Administration

  • 90 mg orally once daily for the first 7 days
  • If 90 mg is tolerated, increase to 180 mg orally once daily
  • May be taken with or without food
  • Tablets should not be crushed or chewed

Interaction

  • CYP3A Inhibitors may increase plasma concentrations
  • CYP3A Inducers may decrease plasma concentrations
  • CYP3A Substrates may have altered plasma concentrations

Contraindications

  • Known hypersensitivity to Brigatinib or any other components

Side Effects

  • Interstitial Lung Disease (ILD)/Pneumonitis
  • Hypertension
  • Bradycardia
  • Visual Disturbance
  • Creatine Phosphokinase (CPK) Elevation
  • Pancreatic Enzyme Elevation
  • Hyperglycemia

Pregnancy & Lactation

  • No clinical data on use in pregnant women
  • Adverse reactions in breastfed infants
  • Advice on effective non-hormonal contraception
  • Potential for reduced fertility in males

Precautions & Warnings

  • Severe pulmonary adverse reactions
  • Hypertension monitoring and control
  • Bradycardia monitoring
  • Visual disturbance monitoring
  • CPK and pancreatic enzyme elevation monitoring
  • Hyperglycemia monitoring

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of reach of children

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