Angilock Plus 50 mg+12.5 mg (Tablet)

Title

• Angilock Plus

Categories

• Medicine
• Antihypertensive
• Diuretic

Description

• Angilock Plus is indicated for the treatment of hypertension and to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy.
• Angiotensin II formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme (ACE), is a potent vasoconstrictor, the primary vasoactive hormone of the renin-angiotensin system and an important component in the pathophysiology of hypertension.
• Losartan and its principal active metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT₁ receptor found in many tissues.
• Hydrochlorothiazide is a thiazide diuretic affecting the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of Sodium and Chloride.
• The usual starting dose of this combination 50/12.5 is one tablet once daily for hypertension.
• This preparation may be administered with other antihypertensive agents and may be administered with or without food.
• Contraindicated in patients who are hypersensitive to any component of this product or with anuria or hypersensitivity to other sulfonamide-derived drugs.
• Symptomatic hypotension, hyperkalaemia, and occasional angioedema may occur as side-effects.
• Angiotensin-II receptor antagonists should be avoided in pregnancy unless essential and are not recommended in breastfeeding.
• Hypersensitivity, periodic determination of serum electrolytes, hypokalemia, impaired renal function, and symptomatic hypotension should be monitored.
• Use in pediatric patients, hepatic impairment, and overdose effects of Losartan Potassium and Hydrochlorothiazide.

Size

• Tablet

Package Quantity

• 30
• 60
• 90

Active Ingredients

• Losartan Potassium
• Hydrochlorothiazide

Strength

• 50/12.5 mg
• 100/25 mg

Color Options

• White

Dosage Instructions

• 50/12.5 is one tablet once daily for hypertension, may increase to 100/25 once daily if required.
• Starting dose for initial treatment of severe hypertension is one tablet of 50/12.5 once daily, may increase to 100/25 once daily if necessary.

Administration

• May be administered with other antihypertensive agents.
• May be administered with or without food.

Interactions

• No significant drug-drug pharmacokinetic interactions with Hydrochlorothiazide, Digoxin, Warfarin, Cimetidine, and Phenobarbital.
• Concomitant use of potassium-sparing diuretics or potassium supplements may lead to an increase in serum potassium.
• Interactions with alcohol, barbiturates, narcotics, antidiabetic drugs, other antihypertensive drugs, and cholestyramine and colestipol resins.
• Absorption of Hydrochlorothiazide is impaired in the presence of anionic exchange resins.

Contraindications

• Hypersensitivity to any component of the product.
• Anuria or hypersensitivity to other sulfonamide-derived drugs.

Side Effects

• Symptomatic hypotension
• Hyperkalaemia
• Angioedema
• Vertigo
• Gastro-intestinal disturbances
• Angina
• Palpitation
• Oedema
• Dyspnoea
• Headache
• Sleep disorders
• Malaise
• Urticaria
• Pruritus
• Rash
• Hepatitis
• Atrial fibrillation
• Cerebrovascular accident
• Syncope
• Paraesthesia
• Pancreatitis
• Anaphylaxis
• Cough
• Depression
• Erectile dysfunction
• Anaemia
• Thrombocytopenia
• Hyponatraemia
• Arthralgia
• Myalgia
• Renal impairment
• Rhabdomyolysis
• Tinnitus
• Photosensitivity
• Vasculitis

Pregnancy and Lactation

• Avoid use in pregnancy unless essential.
• Not recommended in breastfeeding.
• Alternative treatment options with better-established safety information are available.

Precautions and Warnings

• Hypersensitivity monitoring
• Periodic determination of serum electrolytes
• Hypokalemia monitoring
• Impaired renal function monitoring
• Symptomatic hypotension monitoring.

Special Populations

• Use in Patients with Renal Impairment
• Use in Patients with Hepatic Impairment
• Use in pediatric patients

Overdose Effects

• Manifestation of hypotension and tachycardia.
• Supportive treatment for symptomatic hypotension.
• Hemodialysis not effective for Losartan or its metabolite.
• Signs and symptoms caused by electrolyte depletion.

Therapeutic Class

• Combined antihypertensive preparations

Storage Conditions

• Do not store above 30°C.
• Keep out of the reach of children.

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