Telmitan Max 5 mg+40 mg (Tablet)
Unit Price: ৳ 12.50 (2 x 14: ৳ 350.00)
Strip Price: ৳ 175.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Amlodipine besilate telmisartan |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- treatment of hypertension
- using as initial therapy in patients needing multiple drugs for blood pressure control
- antihypertensive agent
Pharmacology
- fixed dose combination of Telmisartan and Amiodipine
- non-peptide angiotensin receptor blocker
- principal pressor agent of the renin-angiotensin system
- dihydropyridine calcium-channel blocker
- selective blocking of angiotensin II binding to AT1 receptor
- peripheral arterial vasodilator
- reduction in peripheral vascular resistance
- reduction in blood pressure
- inhibition of calcium ion influx into vascular smooth muscle and cardiac muscle
Dosage & Administration
- initial therapy starting dose of 40/5 mg once daily
- larger blood pressure reductions with 80/5 mg once daily
- add-on therapy for patients not adequately controlled with individual components
- replacement therapy for patients receiving individual components from separate tablets
- maximum recommended dose of 80/10 mg once daily
Interaction
- co-administration with acetaminophen, glyburide, simvastatin, hydrochlorothiazide, warfarin, ibuprofen, thiazide diuretics, beta-blockers, angiotensin converting enzyme inhibitors, long-acting nitrates, sublingual nitroglycerin, digoxin, non-steroidal anti-inflammatory drugs, antibiotics, and oral hypoglycemic drugs
- possible inhibition of CYP2C19 metabolism
Contraindications
- known hypersensitivity to the product or any of its components
- pregnancy & lactation
- biliary obstructive disorders, severe hepatic impairment, hypotension, cardiogenic shock, left ventricle outflow tract obstruction
Side Effects
- dizziness
- peripheral edema
- migraine
- headache
- paraesthesia
- vertigo
- bradycardia
- palpitations
- hypotension
- cough
- abdominal pain
- diarrhea
- nausea
- pruritus
- myalgia
- spasm
- erectile dysfunction
- chest pain
- fatigue
Pregnancy & Lactation
- Pregnancy Categories C (first trimester) and D (second and third trimesters)
- excretion of telmisartan and amiodipine in human milk
- discontinuation of nursing or drug after considering importance to the mother
Precautions & Warnings
- avoid fetal or neonatal exposure
- correct volume or salt depletion before initiating therapy
- observe for signs and symptoms of hypotension
- titrate slowly in patients with hepatic or severe renal impairment
- monitor for worsening heart failure
- avoid concomitant use of an ACE inhibitor and angiotensin receptor blocker
- possible myocardial infarction in patients with severe obstructive coronary artery disease
Use in Special Populations
- pediatric use not established
- initial therapy not recommended in patients ≥75 years old
- initial therapy not recommended in hepatically impaired patients
Overdose Effects
- manifestations of overdose: hypotension, dizziness, tachycardia, bradycardia
- supportive treatment for symptomatic hypotension
- excessive peripheral vasodilation with marked hypotension and possibly reflex tachycardia
- active cardiac and respiratory monitoring for massive overdose
Therapeutic Class
- combined antihypertensive preparations
Storage Conditions
- do not store above 30°C
- protect from light and high humidity
- keep out of the reach of children