Vorifast 200 mg/5 ml (Powder for Suspension)

40 ml bottle: ৳ 1,000.00

Medicine Details

Category Details
Generic Voriconazole
Company Healthcare pharmaceuticals ltd
Also available as
Vorifast 200 mg tablet Vorifast 200 mg injection Vorifast 50 mg tablet Vorifast 100 mg tablet

Indications

  • Age Group:
    • 12 years and older
  • Treatment for:
    • Invasive aspergillosis
    • Candidemia
    • Disseminated candidiasis
    • Esophageal candidiasis
    • Serious infections caused by Scedosporium apiospermum
    • Fusarium Species infections

Pharmacology

  • Medication Type: Triazole antifungal
  • Mechanism of Action: Inhibition of CYP450-dependent 14-alpha sterol demethylase
  • Resulting Effect: Depletion of ergosterol in fungal cell membrane

Dosage & Administration

  • Administration Forms:
    • Oral
    • Injection
  • Oral Dosage:
    • 40kg and over:
      • Loading dose: 400mg or 10ml every 12 hours for the first 24 hours
      • Maintenance dose: 200mg or 5ml twice daily after 24 hours
    • Below 40kg:
      • Loading dose: 200mg or 5ml every 12 hours for the first 24 hours
      • Maintenance dose: 100mg or 2.5ml twice daily after 24 hours
  • Injection Dosage:
    • Invasive Aspergillosis:
      • Loading dose: 6mg/kg 12 hourly for the first 24 hours
      • Maintenance Dose: 4mg/kg 12 hourly
    • Candidemia and other deep tissue Candida infections:
      • Loading dose: 6mg/kg 12 hourly for the first 24 hours
      • Maintenance Dose: 3-4mg/kg 12 hourly
    • Scedosporiosis and Fusariosis:
      • Loading dose: 6mg/kg 12 hourly for the first 24 hours
      • Maintenance Dose: 4mg/kg 12 hourly

Interaction

  • Impact on Enzymes:
    • CYP3A4
    • CYP2C9
    • CYP2C19
  • Effects:
    • Adjustment of dosage and monitoring for adverse reactions
    • Potential increase in concentrations and activity of other drugs
    • Increased maintenance dosage with specific co-administered drugs

Contraindications

  • Hypersensitivity: Known hypersensitivity to Voriconazole or its components
  • Co-administration Risk:
    • Terfenadine
    • Astemizole
    • Cisapride
    • Pimozide
    • Quinidine
    • Sirolimus
    • Rifampin
    • Carbamazepine
    • Long-acting barbiturates
    • Efavirenz
    • Ritonavir
    • Rifabutin
    • Ergot alkaloids
    • St. John's Wort

Side Effects

  • Common:
    • Abdominal pain
    • Anemia
    • Blurred vision
    • Headache
    • Chest pain
    • Nausea
    • Diarrhea

Pregnancy & Lactation

  • Usage during Pregnancy: Should be used only if potential benefit justifies potential risk to the fetus

Precautions & Warnings

  • Long term exposure: Careful assessment for benefit-risk balance for treatments exceeding 180 days
  • Reported Risk: Squamous cell carcinoma of the skin related to long-term Voriconazole treatment

Overdose Effects

  • Information: No specific data available

Use in Special Populations

  • Efficacy in Children: Efficacy not established for children under 12 years of age

Therapeutic Class

  • Classification: Other Antifungal preparations

Reconstitution

  • Suspension Instructions: Reconstitution instructions provided. Store reconstituted suspension between 15°C to 30°C. Discard after 14 days.

Storage Conditions

  • Recommendations: Store in a dry place, below 25°C temperature, protected from light. Store Voriconazole powder for suspension between 2°C to 8°C temperature.

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