Apetiz 200 mg/5 ml (Oral Suspension)
100 ml bottle: ৳ 500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Megestrol acetate |
| Company | Aristopharma ltd |
| Also available as |
Indications
- Palliative treatment of advanced carcinoma of the breast or endometrium
- Treatment of anorexia and cachexia
- Treatment of unexplained significant weight loss in patients with AIDS
- Not a substitute for surgery, radiation, or chemotherapy
Pharmacology
- Synthetic antineoplastic and progestational drug
- Inhibition of pituitary gonadotrophin production
- Decrease in estrogen secretion
- Modifying the action of steroid hormones
- Direct cytotoxic effect on tumor cells
- Estimates of plasma levels after oral dose
- Peak plasma concentrations occur 2 to 3 hours after a single oral dose
- Plasma half-life
- Excretion in urine and feces
Dosage & Administration
- Tablet dosage for breast cancer
- Tablet dosage for endometrial carcinoma
- Recommended adult initial dosage of oral suspension
Interaction
- Possible interactions with concomitant medications not investigated
- Possible fluid retention with estrogens and progestogens
Contraindications
- History of hypersensitivity to megestrol acetate
- Known or suspected pregnancy
Side Effects
- Weight gain
- Thromboembolic phenomena
- Glucocorticoid effects
- Nausea
- Dyspnea
- Hyperglycemia
- Alopecia
- Hypertension
- Mood changes
- Rash
Pregnancy & Lactation
- Pregnancy Category D
- Not recommended during the first four months of pregnancy
- Excretion in mother's milk
- Nursing should be discontinued during treatment
Precautions & Warnings
- Close surveillance for cancer patients
- Use with caution in patients with a history of thromboembolic disease
- Exacerbation of preexisting diabetes
Use in Special Populations
- Safety and effectiveness in pediatric patients not established
- Insufficient data from clinical studies in patients 65 years and older
Overdose Effects
- No serious unexpected side effects at high dosages
Storage Conditions
- Store in a cool and dry place
- Keep away from light and moisture
- Keep out of reach of children