Actemra 400 mg/20 ml (IV Infusion)
20 ml vial: ৳ 49,242.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tocilizumab |
| Company | Roche bangladesh ltd |
| Also available as |
Indications
- Rheumatoid Arthritis
- Polyarticular Juvenile Idiopathic Arthritis
- Systemic Juvenile Idiopathic Arthritis
- COVID-19 Treatment
- Cytokine Release Syndrome
- Giant Cell Arteritis
- Systemic Sclerosis-Associated Interstitial Lung Disease
Pharmacology
- Recombinant humanized anti-human interleukin 6 (IL-6) receptor monoclonal antibody
- Immunoglobulin IgG1K subclass
- Binds to soluble and membrane-bound IL-6 receptors
- Inhibits IL-6-mediated signaling
- Produced by a variety of cell types
Dosage & Administration
- Intravenous infusion
- As monotherapy or with other non-biologic DMARDs
- Recommended dosage based on body weight
- Different dosage regimens for different conditions
- Maximum dosage for specific conditions
Interaction
- Cautions for coadministering with CYP3A4 substrate drugs
- Effect on CYP450 enzyme activity
Contraindications
- Known hypersensitivity to Tocilizumab
Side Effects
- Common adverse reactions
- Specific adverse reactions in COVID-19 patients
Pregnancy & Lactation
- Potential fetal harm based on animal data
- Use during pregnancy if benefits justify risks
- Consideration for breastfeeding individuals with COVID-19
Precautions & Warnings
- Do not administer during active infection
- Evaluation for tuberculosis risk factors
- Caution in patients at increased risk of gastrointestinal perforation
- Monitoring for signs and symptoms of hepatic injury
- Hypersensitivity reactions and anaphylaxis
- Avoidance of live vaccines
- Initiation criteria based on blood counts and liver function tests
Use in Special Populations
- Safety and effectiveness in pediatric and geriatric patients
- Caution in treating the elderly
- Safety and efficacy in hepatic and renal impairment
Overdose Effects
- Patient monitoring for adverse reactions
Therapeutic Class
- Drugs used for Rheumatoid Arthritis
Storage Conditions
- Temperature range for storage
- Avoid freezing