Larb Plus 50 mg+12.5 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 14: ৳ 420.00)
Strip Price: ৳ 140.00

Medicine Details

Category Details
Generic Losartan potassium hydrochlorothiazide
Company Opsonin pharma ltd
Also available as
Larb plus 100 mg tablet Larb plus 100 mg tablet

Indications

  • Treatment of hypertension
  • Reducing the risk of stroke in patients with hypertension and left ventricular hypertrophy

Pharmacology

  • Losartan blocking the vasoconstrictor and aldosterone-secreting effects of angiotensin II
  • Hydrochlorothiazide's effect on renal tubular mechanisms of electrolyte reabsorption

Dosage

  • Usual starting dose of 50/12.5 is one tablet once daily
  • Dosage may be increased to 100/25 once daily for non-responding patients
  • Antihypertensive effect attained within three weeks after initiation of therapy

Administration

  • May be administered with other antihypertensive agents
  • May be administered with or without food

Interaction

  • Potential interaction with potassium-sparing diuretics and salt substitutes
  • Interaction with antidiabetic drugs and other antihypertensive drugs

Contraindications

  • Contraindicated in patients hypersensitive to any component
  • Contraindicated in patients with anuria or hypersensitivity to sulfonamide-derived drugs

Side Effects

  • Symptomatic hypotension including dizziness
  • Hyperkalaemia
  • Angioedema
  • Vertigo
  • Gastro-intestinal disturbances

Pregnancy & Lactation

  • Angiotensin-II receptor antagonists should be avoided in pregnancy unless essential
  • Not recommended in breastfeeding

Precautions & Warnings

  • Periodic determination of serum electrolytes
  • Hypokalemia may rarely develop
  • Impaired renal function

Use in Special Populations

  • Usual therapy regimens may be followed in patients with creatinine clearance >30 ml/min
  • Not recommended in patients with hepatic impairment

Overdose Effects

  • Manifestations of overdosage include hypotension, tachycardia, and bradycardia
  • Supportive treatment should be instituted for symptomatic hypotension

Therapeutic Class

  • Combined antihypertensive preparations

Storage Conditions

  • Do not store above 30°C
  • Keep out of the reach of children

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