Anefer 200 mg/10 ml (IV Injection or Infusion)

Title

• Iron Sucrose Injection USP

Categories

• Medicine
• Pharmaceutical
• Healthcare

Description

• Treatment of Anefer deficiency
• Intravenous administration
• Indicated for various patient populations

Indications

• Rapid Anefer supply
• Patients intolerant to oral Anefer therapy
• In active inflammatory bowel disease
• Chronic kidney disease patients
• Surgical procedures
• Postpartum patients

Pharmacology

• Iron Sucrose is haematinic
• Contains Polynuclear Iron (III) Hydroxide in Sucrose
• Dissociates into Iron and Sucrose
• Iron transferred to liver and bone marrow
• Iron binds to plasma transferrin

Dosage

• 5-10 ml Iron Sucrose Injection once to three times a week for adults and elderly
• 0.15 ml Iron Sucrose Injection per kg body weight for children

Administration

• Intravenous injection
• Infusion with dilution of 1 ml Iron Sucrose Injection in 20 ml 0.9% w/v Sodium Chloride
• Test dose before therapeutic dose

Interaction

• Not studied with other drugs
• Should not be administered concomitantly with oral iron preparations

Contraindications

• Evidence of Iron overload
• Known hypersensitivity to Iron Sucrose or its components
• Anaemia not caused by Iron deficiency
• History of allergic disorders, liver disease, infections

Side effects

• Hypotension
• Nausea
• Headache
• Vomiting
• Diarrhea
• Fever
• Chest pain
• Dyspnea
• Hypersensitivity reactions

Pregnancy lactation

• Pregnancy Category-B
• Caution during nursing

Precautions warnings

• Caution with tissue Iron overload
• Periodic monitoring of hematologic parameters
• Hypersensitivity reactions
• Hypotension risk

Special populations

• Limited safety data in pediatric patients
• No overall differences in safety observed between elderly and younger subjects
• Administration guidelines for different CKD patient types

Overdose effects

• Accumulation in storage sites leading to hemosiderosis
• Monitoring of serum ferritin and transferrin saturation
• Symptoms include hypotension, headache, vomiting, nausea, dizziness, joint aches

Drug classes

• Parenteral Iron Preparations

Storage conditions

• Store in cool and dry place
• Protected from light
• Do not freeze

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