Esoz 20 mg (Capsule (Enteric Coated))

Title

• Esoz 20 mg Capsule

Categories

• Medicine
• Healthcare
• Pharmaceutical

Description

• Proton pump inhibitor
• Relief from chronic heartburn symptoms
• Healing of erosive esophagitis
• Maintenance of healing of erosive esophagitis
• Eradication of Helicobacter pylori infection
• Treatment for Zollinger-Ellison Syndrome
• Acid-related Dyspepsia relief
• Treatment for Duodenal & Gastric ulcers
• Pharmacology information
• Oral and IV dosage instructions
• Administration guidelines
• Interaction with other drugs
• Contraindications
• Common side effects
• Pregnancy & Lactation precautions
• Special population uses
• Overdose effects
• Storage conditions
• Chemical structure

Dimensions

• 20 mg
• 40 mg

DosageForm

• Capsule
• Tablet
• Oral suspension
• IV Injection
• IV Infusion

ColorOptions

• White

Functions

• Suppresses gastric acid secretion
• Healing of esophagitis
• Eradication of H. pylori infection

Materials

• Esomeprazole magnesium
• Enteric-coated pellet formulation

TechnicalSpecifications

• Peak plasma levels occur at approximately 1.5 hours
• Plasma protein binding is constant over the concentration range of 2-20 mmol/L
• Approximate elimination half-life is 1-1.5 hours
• 97% bound to plasma proteins
• Metabolized in the liver by the CYP enzyme system
• Less than 1% of parent drug is excreted in the urine

DesignElements

• Clear and colorless to very slightly yellow reconstituted IV injection solution

UsabilityFeatures

• Swallowed whole and taken one hour before a meal
• Can be administered through a nasogastric or gastric tube
• Can be used with antacids

PrecautionsAndWarnings

• Symptomatic response to therapy does not preclude the presence of gastric malignancy
• Caution in difficulty swallowing capsules
• Appropriate use with antacids

SpecialPopulations

• Paediatric use
• Geriatric use
• Hepatic insufficiency
• Renal insufficiency

StorageConditions

• Store at a temperature not exceeding 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children

ChemicalStructure

• Molecular formula: C17H19N3O3S
• Chemical structure image available

DosageInstructions

• Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
• Maintenance of Healing of Erosive Esophagitis: 20 mg Once Daily

ModeOfAction

• Suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase
• Provides better acid control than racemic proton pump inhibitors
• Absorption of esomeprazole capsules

Interaction

• Extensively metabolized in the liver by CYP2C19 and CYP3A4
• No clinically relevant interactions with specific drugs expected
• Potential interference with CYP2C19
• Combination therapy with clarithromycin increases plasma levels

Contraindications

• Known hypersensitivity to any of the formulation

SideEffects

• Headache
• Diarrhoea
• Nausea
• Flatulence
• Abdominal pain
• Constipation
• Dry mouth

PregnancyAndLactation

• No adequate and well-controlled studies in pregnant women
• No teratogenic effects observed in animal studies
• Breastfeeding should be discontinued if essential

OverdoseEffects

• Acute toxicity signs in rats
• No specific antidote known
• Treatment should be symptomatic and supportive

CommonlyAskedQuestions

• Detailed information on uses, side effects, and precautions

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